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Neurotoxicity in zebrafish exposed to carbon nanotubes: Effects on neurotransmitters levels and antioxidant system

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dc.contributor.authorRocha, A. M. da
dc.contributor.authorKist, L. W.
dc.contributor.authorAlmeida, E. A. [UNESP]
dc.contributor.authorSilva, D. G. H. [UNESP]
dc.contributor.authorBonan, C. D.
dc.contributor.authorAltenhofen, S.
dc.contributor.authorKaufmann Jr, C. G.
dc.contributor.authorBogo, M. R.
dc.contributor.authorBarros, D. M.
dc.contributor.authorOliveira, S.
dc.contributor.authorGeraldo, V
dc.contributor.authorLacerda, R. G.
dc.contributor.authorFerlauto, A. S.
dc.contributor.authorLadeira, Luiz Orlando
dc.contributor.authorMonserrat, J. M.
dc.contributor.institutionUniv Fed Rio Grande FURG
dc.contributor.institutionRede Nanotoxicol MCTI CNPq
dc.contributor.institutionInst Nacl Ciencia & Tecnol Nanomat Carbono CNPq
dc.contributor.institutionFac Biociencias PUCRS INCT TM CNPq
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2019-10-04T11:57:22Z
dc.date.available2019-10-04T11:57:22Z
dc.date.issued2019-04-01
dc.description.abstractGiven the increasing use of carbon nanotubes (CNT) in several industries and technological applications, it is essential to perform in vivo toxicological studies with these nanomaterials to evaluate their potential ecotoxicity. Dopamine (DA) and serotonin (5HT) are key neurotransmitters for brain functions and behavioral responses. Determination of DA and 5HT were performed in brain samples from zebrafish Danio rerio exposed i.p. to single-walled CNT (SWCNT), besides analyzing acetylcholinesterase (AChE) and ectonucleotidases activity, lipid peroxidation and total antioxidant capacity. Results showed that treatment with SWCNT increased between 3 and 6-fold the concentration of DA and 5HT (p < 0.05). Similarly, a significant reduction (p < 0.05) in AChE activity was observed in the brains of SWCNT exposed zebrafish when compared to the control groups. Cholinergic, serotonergic, and dopaminergic systems, through AChE activity and serotonin and dopamine levels, respectively were affected by SWCNT in the zebrafish brain. Alterations in these neurotransmitters can potentially affect several physiological and behavioral that they control.en
dc.description.affiliationUniv Fed Rio Grande FURG, ICB, Av Italia Km 8 S-N,Cx P 474, BR-96200970 Rio Grande, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande FURG, ICB, Progmma Posgrad Ciencias Fisiol FAC, Rio Grande, RS, Brazil
dc.description.affiliationRede Nanotoxicol MCTI CNPq, Brasilia, DF, Brazil
dc.description.affiliationInst Nacl Ciencia & Tecnol Nanomat Carbono CNPq, Belo Horizonte, MG, Brazil
dc.description.affiliationFac Biociencias PUCRS INCT TM CNPq, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Estadual Paulista, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipInstituto Nacional de Ciencia e Tecnologia Nanomaterial de Carbono
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 421701/2017-0
dc.format.extent30-35
dc.identifierhttp://dx.doi.org/10.1016/j.cbpc.2018.12.008
dc.identifier.citationComparative Biochemistry And Physiology C-toxicology & Pharmacology. New York: Elsevier Science Inc, v. 218, p. 30-35, 2019.
dc.identifier.doi10.1016/j.cbpc.2018.12.008
dc.identifier.issn1532-0456
dc.identifier.urihttp://hdl.handle.net/11449/184379
dc.identifier.wosWOS:000459838300005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry And Physiology C-toxicology & Pharmacology
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectNanotoxicology
dc.subjectNanomaterials
dc.subjectFish
dc.subjectNeurotransmitters
dc.subjectNeurotoxicity
dc.titleNeurotoxicity in zebrafish exposed to carbon nanotubes: Effects on neurotransmitters levels and antioxidant systemen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0002-4935-6070[14]

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