Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative

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dc.contributor.authorde Moura, Aniele [UNESP]
dc.contributor.authorGaglieri, Caroline [UNESP]
dc.contributor.authorda Silva-Filho, Luiz Carlos [UNESP]
dc.contributor.authorCaires, Flávio Junior [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T01:30:39Z
dc.date.available2020-12-12T01:30:39Z
dc.date.issued2020-01-01
dc.description.abstractThe curcumin is the major constituent of turmeric plant (Curcuma longa), which presents several biological activities such as antioxidant, bactericidal, anti-inflammatory and antitumor. An interesting strategy to improve its properties is to synthetize curcumin derivatives. Thus, the synthesis of a new curcumin derivative (DCUR) with 4-carboxybenzaldehyde (4-CBA) becomes interesting, which occurs by a Knoevenagel reaction, a common methodology used to synthesize curcumin analogues. The synthesis was carried out by the mechanochemical method, which is an efficient green method for the synthesis of organic compounds. The most efficient grinding time for mechanochemical synthesis was determined using PXRD and DSC techniques. 1H NMR, DEPTQ and FTIR analyses confirmed the structure of DCUR. This new methodology is more efficient (at least 5×), and cleaner than usual methods described in the literature to obtain a new compound by Knoevenagel reaction. The TG–DTA, DSC and DSC-microscopy techniques were used to confirm the formation of the compound and to study its thermal behavior. Moreover, the thermoanalytical of 4-CBA showed that this compound presents a reversible solid–solid phase transition.en
dc.description.affiliationChemistry Department School of Sciences UNESP - São Paulo State University
dc.description.affiliationUnespChemistry Department School of Sciences UNESP - São Paulo State University
dc.identifierhttp://dx.doi.org/10.1007/s10973-020-10000-w
dc.identifier.citationJournal of Thermal Analysis and Calorimetry.
dc.identifier.doi10.1007/s10973-020-10000-w
dc.identifier.issn1588-2926
dc.identifier.issn1388-6150
dc.identifier.scopus2-s2.0-85087771590
dc.identifier.urihttp://hdl.handle.net/11449/199096
dc.language.isoeng
dc.relation.ispartofJournal of Thermal Analysis and Calorimetry
dc.sourceScopus
dc.subject4-Carboxybenzaldehyde
dc.subjectCurcuminoids
dc.subjectKnoevenagel reaction
dc.subjectMechanochemistry
dc.subjectSolid–solid phase transition
dc.subjectThermal analysis
dc.titleMechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivativeen
dc.typeArtigo
unesp.author.orcid0000-0003-3187-2111[4]

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