Malignant epitheliod hemangioendothelioma of the thyroid: a case report
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França, Mariana M. [UNESP]
Souza, Gregório L. [UNESP]
Frank, Michell [UNESP]
Fabris, Viciany Erique [UNESP]
Tagliarini, José Vicente [UNESP]
Mazeto, Gláucia [UNESP]
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Primary malignant epithelioid hemangioendothelioma (MEH) of the thyroid is a rare neoplasia with only a few cases reported in the literature. We report a 75 year old man, who presented with a substernal goiter and compressive symptoms. Ultrasonographic evaluation revealed a hypoechogenic nodule in the left lobe, measuring 4.1 cm in maximum diameter, and associated gross calcifications. Fine needle aspiration yielded hemorrhagic material. A left thyroid lobectomy and isthmusectomy was performed. The surgical specimen contained a malignant epithelioid hemangioendothelioma measuring 6 x 4 x 3 cm that had infiltrated about 50% of the thyroidal parenchyma, and surrounded a necrotic nodule. Immunohistochemistry results corroborated the histopathological findings; staining was positive for AE1/AE3, CD31, CD34, factor VIII-related antigen, and Ki-67 expression. Because of the patient’s comorbidities, surgical complementation was not undertaken and he has been undergoing conservative treatment.
Thyroid nodules, Hemangioendothelioma, Goiter, Rare neoplasia
Clinical Case Studies, v. 2, n. 2, p. 29-31, 2011.