Epigenetic regulatory mechanisms induced by resveratrol

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dc.contributor.authorFernandes, Guilherme Felipe Santos [UNESP]
dc.contributor.authorSilva, Gabriel Dalio Bernardes [UNESP]
dc.contributor.authorPavan, Aline Renata [UNESP]
dc.contributor.authorChiba, Diego Eidy [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.contributor.authorDos Santos, Jean Leandro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:45Z
dc.date.available2018-12-11T17:34:45Z
dc.date.issued2017-11-01
dc.description.abstractResveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/19531-1
dc.description.sponsorshipIdFAPESP: 2016/08470-4
dc.description.sponsorshipIdFAPESP: 2016/08880-8
dc.description.sponsorshipIdFAPESP: 2016/09502-7
dc.identifierhttp://dx.doi.org/10.3390/nu9111201
dc.identifier.citationNutrients, v. 9, n. 11, 2017.
dc.identifier.doi10.3390/nu9111201
dc.identifier.file2-s2.0-85033466919.pdf
dc.identifier.issn2072-6643
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.scopus2-s2.0-85033466919
dc.identifier.urihttp://hdl.handle.net/11449/179337
dc.language.isoeng
dc.relation.ispartofNutrients
dc.relation.ispartofsjr1,557
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDNA methyltransferase
dc.subjectEpigenetic targets
dc.subjectHistone acetyltransferase
dc.subjectHistone deacetylase
dc.subjectResveratrol
dc.subjectSIRT1
dc.titleEpigenetic regulatory mechanisms induced by resveratrolen
dc.typeResenha
unesp.author.lattes9734333607975413[5]
unesp.author.orcid0000-0002-7644-5466[1]
unesp.author.orcid0000-0002-2249-9856[2]
unesp.author.orcid0000-0002-2460-2829[6]
unesp.author.orcid0000-0003-4141-0455[5]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas