Bone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvaria

dc.contributor.authorBassi, Ana Paula Farnezi [UNESP]
dc.contributor.authorBizelli, Vinícius Ferreira [UNESP]
dc.contributor.authorFrancatti, Tamires Mello [UNESP]
dc.contributor.authorde Moares Ferreira, Ana Carulina Rezende [UNESP]
dc.contributor.authorPereira, Járede Carvalho [UNESP]
dc.contributor.authorAl-Sharani, Hesham Mohammed
dc.contributor.authorLucas, Flavia de Almeida [UNESP]
dc.contributor.authorFaverani, Leonardo Perez [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIbb University
dc.contributor.institutionHarbin Medical University
dc.date.accessioned2021-06-25T11:12:12Z
dc.date.available2021-06-25T11:12:12Z
dc.date.issued2021-02-01
dc.description.abstractBiomaterials for use in guided bone regeneration (GBR) are constantly being investigated and developed to improve clinical outcomes. The present study aimed to comparatively evaluate the biological performance of different membranes during the bone healing process of 8 mm critical defects in rat calvaria in order to assess their influence on the quality of the newly formed bone. Seventy-two adult male rats were divided into three experimental groups (n = 24) based on the membranes used: the CG—membrane-free control group (only blood clot, negative control), BG— porcine collagen membrane group (Bio-Guide®, positive control), and the PCL—polycaprolactone (enriched with 5% hydroxyapatite) membrane group (experimental group). Histological and his-tometric analyses were performed at 7, 15, 30, and 60 days postoperatively. The quantitative data were analyzed by two-way ANOVA and Tukey’s test (p < 0.05). At 7 and 15 days, the inflammatory responses in the BG and PCL groups were significantly different (p < 0.05). The PCL group, at 15 days, showed a large area of newly formed bone. At 30 and 60 days postoperatively, the PCL and BG groups exhibited similar bone healing, including some specimens showing complete closure of the critical defect (p = 0.799). Thus, the PCL membrane was biocompatible, and has the potential to help with GBR procedures.en
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University—UNESP
dc.description.affiliationSchool of Dentistry Faculty of Dentistry Ibb University
dc.description.affiliationDepartment of Maxillofacial Surgery School of Stomatology Harbin Medical University
dc.description.affiliationAraçatuba Veterinary Medicine School UNESP—São Paulo State University
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University—UNESP
dc.description.affiliationUnespAraçatuba Veterinary Medicine School UNESP—São Paulo State University
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2014/24360-9
dc.format.extent1-12
dc.identifierhttp://dx.doi.org/10.3390/membranes11020124
dc.identifier.citationMembranes, v. 11, n. 2, p. 1-12, 2021.
dc.identifier.doi10.3390/membranes11020124
dc.identifier.issn2077-0375
dc.identifier.scopus2-s2.0-85101283956
dc.identifier.urihttp://hdl.handle.net/11449/208437
dc.language.isoeng
dc.relation.ispartofMembranes
dc.sourceScopus
dc.subjectBone regeneration
dc.subjectBone substitute
dc.subjectMaterials biocompatibility
dc.subjectMaterials testing
dc.subjectMembranes
dc.subjectPolycaprolactone
dc.subjectPolymers
dc.titleBone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvariaen
dc.typeArtigo

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