Bone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvaria
dc.contributor.author | Bassi, Ana Paula Farnezi [UNESP] | |
dc.contributor.author | Bizelli, Vinícius Ferreira [UNESP] | |
dc.contributor.author | Francatti, Tamires Mello [UNESP] | |
dc.contributor.author | de Moares Ferreira, Ana Carulina Rezende [UNESP] | |
dc.contributor.author | Pereira, Járede Carvalho [UNESP] | |
dc.contributor.author | Al-Sharani, Hesham Mohammed | |
dc.contributor.author | Lucas, Flavia de Almeida [UNESP] | |
dc.contributor.author | Faverani, Leonardo Perez [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Ibb University | |
dc.contributor.institution | Harbin Medical University | |
dc.date.accessioned | 2021-06-25T11:12:12Z | |
dc.date.available | 2021-06-25T11:12:12Z | |
dc.date.issued | 2021-02-01 | |
dc.description.abstract | Biomaterials for use in guided bone regeneration (GBR) are constantly being investigated and developed to improve clinical outcomes. The present study aimed to comparatively evaluate the biological performance of different membranes during the bone healing process of 8 mm critical defects in rat calvaria in order to assess their influence on the quality of the newly formed bone. Seventy-two adult male rats were divided into three experimental groups (n = 24) based on the membranes used: the CG—membrane-free control group (only blood clot, negative control), BG— porcine collagen membrane group (Bio-Guide®, positive control), and the PCL—polycaprolactone (enriched with 5% hydroxyapatite) membrane group (experimental group). Histological and his-tometric analyses were performed at 7, 15, 30, and 60 days postoperatively. The quantitative data were analyzed by two-way ANOVA and Tukey’s test (p < 0.05). At 7 and 15 days, the inflammatory responses in the BG and PCL groups were significantly different (p < 0.05). The PCL group, at 15 days, showed a large area of newly formed bone. At 30 and 60 days postoperatively, the PCL and BG groups exhibited similar bone healing, including some specimens showing complete closure of the critical defect (p = 0.799). Thus, the PCL membrane was biocompatible, and has the potential to help with GBR procedures. | en |
dc.description.affiliation | Department of Diagnosis and Surgery School of Dentistry São Paulo State University—UNESP | |
dc.description.affiliation | School of Dentistry Faculty of Dentistry Ibb University | |
dc.description.affiliation | Department of Maxillofacial Surgery School of Stomatology Harbin Medical University | |
dc.description.affiliation | Araçatuba Veterinary Medicine School UNESP—São Paulo State University | |
dc.description.affiliationUnesp | Department of Diagnosis and Surgery School of Dentistry São Paulo State University—UNESP | |
dc.description.affiliationUnesp | Araçatuba Veterinary Medicine School UNESP—São Paulo State University | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | CAPES: 001 | |
dc.description.sponsorshipId | FAPESP: 2014/24360-9 | |
dc.format.extent | 1-12 | |
dc.identifier | http://dx.doi.org/10.3390/membranes11020124 | |
dc.identifier.citation | Membranes, v. 11, n. 2, p. 1-12, 2021. | |
dc.identifier.doi | 10.3390/membranes11020124 | |
dc.identifier.issn | 2077-0375 | |
dc.identifier.scopus | 2-s2.0-85101283956 | |
dc.identifier.uri | http://hdl.handle.net/11449/208437 | |
dc.language.iso | eng | |
dc.relation.ispartof | Membranes | |
dc.source | Scopus | |
dc.subject | Bone regeneration | |
dc.subject | Bone substitute | |
dc.subject | Materials biocompatibility | |
dc.subject | Materials testing | |
dc.subject | Membranes | |
dc.subject | Polycaprolactone | |
dc.subject | Polymers | |
dc.title | Bone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvaria | en |
dc.type | Artigo | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatuba | pt |
unesp.department | Clínica, Cirurgia e Reprodução Animal - FMVA | pt |