Mechanisms Involved in the Beneficial Effects of Spironolactone after Myocardial Infarction

Página do item simplificado
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authordos Santos, Priscila P. [UNESP]
dc.contributor.authorRafacho, Bruna P. M. [UNESP]
dc.contributor.authorGonçalves, Andrea F. [UNESP]
dc.contributor.authorSilva, Renata A. C. [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorPolegato, Bertha Furlan [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorPereira, Elenize J. [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity Estadual
dc.date.accessioned2014-05-27T11:30:45Z
dc.date.available2014-05-27T11:30:45Z
dc.date.issued2013-09-30
dc.description.abstractIntroduction:Our objective was to analyze the effect of spironolactone on cardiac remodeling after experimental myocardial infarction (MI), assessed by matricellular proteins levels, cardiac collagen amount and distribution, myocardial tissue metalloproteinase inhibitor-1(TIMP-1) concentration, myocyte hypertrophy, left ventricular architecture, and in vitro and in vivo cardiac function.Methods:Wistar rats were assigned to 4 groups: control group, in which animals were submitted to simulated surgery (SHAM group; n=9); group that received spironolactone and in which animals were submitted to simulated surgery (SHAM-S group, n=9); myocardial infarction group, in which animals were submitted to coronary artery ligation (MI group, n=15); and myocardial infarction group with spironolactone supplementation (MI-S group, n=15). The rats were observed for 3 months.Results:The MI group had higher values of left cardiac chambers and mass index and lower relative wall thicknesses compared with the SHAM group. In addition, diastolic and systolic functions were worse in the MI groups. However, spironolactone did not influence any of these variables. The MI-S group had a lower myocardial hydroxyproline concentration and myocyte cross-sectional area compared with the MI group. Myocardial periostin and collagen type III were lower in the MI-S group compared with the MI-group. In addition, TIMP-1 concentration in myocardium was higher in the MI-S group compared with the MI group.Conclusions:The predominant consequence of spironolactone supplementation after MI is related to reductions in collagens, with discrete attenuation of other remodeling variables. Importantly, this effect may be modulated by periostin and TIMP-1 levels. © 2013 Minicucci et al.en
dc.description.affiliationInternal Medicine Department Botucatu Medical School University Estadual Paulista, Botucatu, São Paulo
dc.description.affiliationDepartment of Microbiology and Immunology Institute of Biosciences University Estadual, Paulista, Botucatu, São Paulo
dc.description.affiliationUnespInternal Medicine Department Botucatu Medical School University Estadual Paulista, Botucatu, São Paulo
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0076866
dc.identifier.citationPLoS ONE, v. 8, n. 9, 2013.
dc.identifier.doi10.1371/journal.pone.0076866
dc.identifier.file2-s2.0-84884732041.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes1590971576309420
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.scopus2-s2.0-84884732041
dc.identifier.urihttp://hdl.handle.net/11449/76670
dc.identifier.wosWOS:000325423500179
dc.language.isoeng
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleMechanisms Involved in the Beneficial Effects of Spironolactone after Myocardial Infarctionen
dc.typeArtigo
dcterms.licensehttp://www.plos.org/open-access/
unesp.author.lattes5016839015394547[12]
unesp.author.lattes1590971576309420
unesp.author.lattes1213140801402647[7]
unesp.author.lattes7438704034471673
unesp.author.lattes4563764623232492[8]
unesp.author.orcid0000-0002-5843-6232[7]
unesp.author.orcid0000-0002-2875-9532[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-84884732041.pdf
Tamanho:
219.49 KB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Artigos - Clínica Médica - FMB