COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis

dc.contributor.authorRangel, Érika B.
dc.contributor.authorde Lucena, Débora D.
dc.contributor.authorAguiar-Brito, Isabella
dc.contributor.authorde Andrade, Luís Gustavo Modelli [UNESP]
dc.contributor.authorVeronese-Araújo, Alexandre
dc.contributor.authorCristelli, Marina P.
dc.contributor.authorTedesco-Silva, Hélio
dc.contributor.authorMedina-Pestana, José O.
dc.contributor.institutionHospital do Rim
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital Israelita Albert Einstein
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T21:08:42Z
dc.date.available2023-03-01T21:08:42Z
dc.date.issued2022-07-25
dc.description.abstractKidney transplant recipients present higher rates of pre-existing comorbidities, in particular diabetes mellitus (DM), hypertension, and cardiac disease. We aimed to verify the main risk factors related to DM that contribute to COVID-19 progression and mortality in a kidney transplant setting. From March to August 2020, we evaluated 300 kidney transplant recipients affected by COVID-19. We used propensity score matching (PSM) to estimate the impact of DM on COVID-19. After matching, all baseline characteristics were well balanced between those with and without DM (n = 100 in each group). Case fatality rate, the requirement of invasive mechanical ventilation (IMV), and acute kidney injury (AKI) were associated with previous fasting blood glucose, and C-reactive protein (CRP), and lactate dehydrogenase (LDH) levels on admission. These findings were similar in kidney transplant patients with and without DM. Glycemia on admission and estimated glomerular filtration rate (eGFR) either on admission or basal correlated to the need of IMV and development of AKI, respectively. Poor glycaemic control, eGFR, markers of inflammation (CRP) and tissue damage (LDH) were indicative of COVID-19 burden in kidney transplant recipients and may be useful tools for risk-stratifying this population, independently of the DM status, during the pandemic.en
dc.description.affiliationHospital do Rim
dc.description.affiliationNephrology Division Federal University of São Paulo
dc.description.affiliationHospital Israelita Albert Einstein
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School University of São Paulo State
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School University of São Paulo State
dc.identifierhttp://dx.doi.org/10.3389/ti.2022.10375
dc.identifier.citationTransplant International, v. 35.
dc.identifier.doi10.3389/ti.2022.10375
dc.identifier.issn1432-2277
dc.identifier.issn0934-0874
dc.identifier.scopus2-s2.0-85136341873
dc.identifier.urihttp://hdl.handle.net/11449/241535
dc.language.isoeng
dc.relation.ispartofTransplant International
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectdiabetes mellitus
dc.subjectkidney transplant
dc.subjectoutcomes
dc.subjectpropensity score
dc.titleCOVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysisen
dc.typeArtigo

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