Exercise training attenuates dexamethasone-induced hypertension by improving autonomic balance to the heart, sympathetic vascular modulation and skeletal musclemicrocirculation

dc.contributor.authorHerrera, Naiara A. [UNESP]
dc.contributor.authorJesus, Isley [UNESP]
dc.contributor.authorShinohara, André L.
dc.contributor.authorDionísio, Thiago J.
dc.contributor.authorSantos, Carlos F.
dc.contributor.authorAmaral, Sandra L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:23:09Z
dc.date.available2018-12-11T17:23:09Z
dc.date.issued2016-01-01
dc.description.abstractObjective: Although aerobic exercise training has been recommended as nonpharmacological treatment of high blood pressure, the mechanisms of training-induced blood pressure lowering effects in dexamethasone (DEX)-induced hypertension remain unclear. Therefore, the aim of this study was to investigate the preventive role of exercise training in counteracting DEX-induced hypertension. Methods: Rats were submitted to aerobic exercise training for 8 weeks or kept sedentary and then treated with DEX (50mg/kg/day, s.c.) or saline injections for 14 days. Thereafter, all rats underwent carotid artery catheterization, and cardiovascular autonomic modulation was evaluated by spectral analysis. In addition, soleus muscle was collected for morphometric and protein level analysis. Results: DEX treatment increased arterial pressure concomitantly with an increase in low-frequency spectral power of systolic arterial pressure and low frequency in pulse interval (94.11 and 58.58%, respectively), and a decrease in high-frequency spectral power of pulse interval (12.05%). Capillary density (25.87%), capillary-To-fibers ratio (21.22%), vascular endothelial growth factor level (15.10%), B-cell lymphoma 2 (Bcl-2) level (16.40%) and Bcl-2/Bcl-2 associated X protein ratio (27.14%) were all decreased after DEX treatment. Exercise training attenuated DEX-induced increase in arterial pressure accompanied by an attenuation of low-frequency spectral power of systolic arterial pressure, low frequency in pulse interval increases and high-frequency spectral power of pulse interval decrease. Training also prevented the decrease in capillary density (R44.43%), capillary-To-fibers ratio (±36.97%), vascular endothelial growth factor (±16.46%), Bcl-2 (±15.21%) protein level and Bcl-2/Bcl- 2-Associated X protein ratio (±30.93%). Conclusion: These results demonstrate that exercise training improves cardiovascular autonomic balance to the heart associated with an improvement in sympathetic modulation of vascular tone and microcirculatory function in the skeletal muscle of DEX-induced.en
dc.description.affiliationJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP
dc.description.affiliationDepartment of Biological Sciences Bauru School of Dentistry University of SãO Paulo
dc.description.affiliationDepartment of Physical Education Science Faculty SãO Paulo State University (UNESP)
dc.description.affiliationUnespJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESP
dc.description.affiliationUnespDepartment of Physical Education Science Faculty SãO Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/18177-7
dc.description.sponsorshipIdFAPESP: 2014/23229-6
dc.format.extent1967-1976
dc.identifierhttp://dx.doi.org/10.1097/HJH.0000000000001032
dc.identifier.citationJournal of Hypertension, v. 34, n. 10, p. 1967-1976, 2016.
dc.identifier.doi10.1097/HJH.0000000000001032
dc.identifier.issn1473-5598
dc.identifier.issn0263-6352
dc.identifier.scopus2-s2.0-84978758571
dc.identifier.urihttp://hdl.handle.net/11449/176931
dc.language.isoeng
dc.relation.ispartofJournal of Hypertension
dc.relation.ispartofsjr1,733
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectApoptosis
dc.subjectArterial pressure
dc.subjectGlucocorticoids
dc.subjectPhysical training
dc.subjectSpectral analysis
dc.titleExercise training attenuates dexamethasone-induced hypertension by improving autonomic balance to the heart, sympathetic vascular modulation and skeletal musclemicrocirculationen
dc.typeArtigo
unesp.departmentCiências Biológicas - FCpt

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