Publicação:
Influence of treatment with quercetin on lipid parameters and oxidative stress of pregnant diabetic rats

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dc.contributor.authorPereira Braga, Camila [UNESP]
dc.contributor.authorMomentti, Ana Carolina [UNESP]
dc.contributor.authorBarbosa Peixoto, Fernando [UNESP]
dc.contributor.authorde Fátima Ferreira Baptista, Rafaela [UNESP]
dc.contributor.authordos Santos, Felipe André [UNESP]
dc.contributor.authorFava, Fábio Henrique [UNESP]
dc.contributor.authorFernandes, Ana Angélica Henrique [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:20Z
dc.date.available2014-05-27T11:28:20Z
dc.date.issued2013-02-01
dc.description.abstractAmong the numerous coadjuvant therapies that could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect of quercetin on biochemical parameters in streptozotocin-induced (60 mg/kg body mass, by intraperitoneal injection) diabetic rats. A total of 32 female Wistar rats were distributed among 4 groups as follows: control (G1); control treated with quercetin (G2); diabetic (G3); and diabetic treated with quercetin (G4). Quercetin administered to pregnant diabetic rats controlled dyslipidemia and improved lipid profiles in diabetes mellitus, regulated oxidative stress by reducing the generation of lipid hydroperoxides, and increased the activity of the antioxidant enzyme glutathione peroxidase.en
dc.description.affiliationDepartamento de Química e Bioquímica Instituto de Biociências, Campus de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, 18618-970, Botucatu, SP
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências, Campus de Botucatu Universidade Estadual Paulista 'Júlio de Mesquita Filho', UNESP, 18618-970, Botucatu, SP
dc.description.affiliationUnespDepartamento de Química e Bioquímica Instituto de Biociências, Campus de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, 18618-970, Botucatu, SP
dc.description.affiliationUnespDepartamento de Farmacologia Instituto de Biociências, Campus de Botucatu Universidade Estadual Paulista 'Júlio de Mesquita Filho', UNESP, 18618-970, Botucatu, SP
dc.format.extent171-177
dc.identifierhttp://dx.doi.org/10.1139/cjpp-2012-0173
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, v. 91, n. 2, p. 171-177, 2013.
dc.identifier.doi10.1139/cjpp-2012-0173
dc.identifier.issn0008-4212
dc.identifier.issn1205-7541
dc.identifier.lattes3589137264364456
dc.identifier.orcid0000-0001-7264-3396
dc.identifier.scopus2-s2.0-84874636972
dc.identifier.urihttp://hdl.handle.net/11449/74522
dc.identifier.wosWOS:000315789900011
dc.language.isoeng
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.relation.ispartofjcr2.210
dc.relation.ispartofsjr0,724
dc.relation.ispartofsjr0,724
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectDiabetes mellitus
dc.subjectLipid profile
dc.subjectOxidative stress
dc.subjectPregnancy
dc.subjectQuercetin
dc.subjectantidiabetic agent
dc.subjectglutathione peroxidase
dc.subjectlipid hydroperoxide
dc.subjectquercetin
dc.subjectstreptozocin
dc.subjectanimal experiment
dc.subjectantidiabetic activity
dc.subjectbiochemistry
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdyslipidemia
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectfood intake
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpregnancy diabetes mellitus
dc.subjectpriority journal
dc.subjectrat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectBlood Glucose
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetes Mellitus, Type 1
dc.subjectFemale
dc.subjectGlutathione Peroxidase
dc.subjectLipid Peroxides
dc.subjectLipids
dc.subjectMale
dc.subjectOxidative Stress
dc.subjectPregnancy in Diabetics
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTreatment Outcome
dc.titleInfluence of treatment with quercetin on lipid parameters and oxidative stress of pregnant diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.nrcresearchpress.com/page/authors/information/rights
dspace.entity.typePublication
unesp.author.lattes0077247086732148[7]
unesp.author.lattes3589137264364456[5]
unesp.author.orcid0000-0001-7264-3396[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt
unesp.departmentQuímica e Bioquímica - IBBpt

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Botucatu - IBB - Instituto de Biociências