Effect of Citrus aurantium l. essential oil on muscle regeneration in mdx mice

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dc.contributor.authorTome de Souza, Paula Aiello [UNESP]
dc.contributor.authorMarques, Maria Julia
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.authorMichelin Matheus, Selma Maria
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:49:57Z
dc.date.available2014-05-20T13:49:57Z
dc.date.issued2011-01-01
dc.description.abstractDuchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder characterized by the progressive loss of muscular strength. Mdx mutant mice show a marked deficiency in dystrophin, which was related to muscle membrane stability. The aim of this study was to verify the possible protective anti-inflammatory effect of citrus oil on mdx muscle fibers. Thus, adult male and female mdx mice (014/06-CEEA) were divided into control and citrus-treated. After 60 days of treatment, one ml of blood was collected for creatine kinase (CK) test. Diaphragm, sternomastoideus, anterior tibial and gastrocnemius muscles were removed and processed according to histological routine methods. The observed alterations indicate a direct effect of citrus. Recent studies have improved the diagnosis of muscular diseases but with no definitions of efficient treatments. Intervention with several therapies is important to many patients presenting muscular dystrophy, which enables them to live longer and be more active, while there is no development of gene therapies.en
dc.description.abstractLa distrofia muscular de Duchenne (DMD) es una enfermedad grave ligada al cromosoma X, trastorno recesivo que se caracteriza por la pérdida progresiva de fuerza muscular. Mdx ratones mutantes muestran una marcada deficiencia en la distrofina, que está relacionada con la estabilidad de la membrana muscular. El objetivo de este estudio fue comprobar el posible efecto protector, antiinflamatorio del aceite de cítricos en las fibras musculares mdx. Los ratones mdx adultos machos y hembras (014/06-CEEA) se dividieron en control y cítricos tratados. Después de 60 días de tratamiento, un ml de sangre fue recogida para cuantificar la creatina quinasa (CK) de prueba. Fueron retirados y procesados los músculos diafragma, esternomastoideo, tibial anterior y gastrocnemio de acuerdo con los métodos de rutina histológica. Las alteraciones observadas indican un efecto directo de los cítricos. Estudios recientes han mejorado el diagnóstico de enfermedades musculares, pero sin definiciones de tratamientos eficaces. Intervención con varias terapias es importante para muchos pacientes que presentan distrofia muscular, lo que les permite vivir más y ser más activos, mientras no exista desarrollo de terapias génicas.es
dc.description.affiliationSão Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu Municipality, SP, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Inst Biol, Dept Anat, Campinas Municipality, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Inst Biosci, Dept Physiol, Botucatu Municipality, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu Municipality, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Biosci, Dept Physiol, Botucatu Municipality, SP, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFUNDUNESP: 01268/11-DFP
dc.format.extent1357-1363
dc.identifierhttp://dx.doi.org/10.4067/S0717-95022011000400048
dc.identifier.citationInternational Journal of Morphology. Temuco: Soc Chilena Anatomia, v. 29, n. 4, p. 1357-1363, 2011.
dc.identifier.fileS0717-95022011000400048.pdf
dc.identifier.issn0717-9502
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.scieloS0717-95022011000400048
dc.identifier.urihttp://hdl.handle.net/11449/17818
dc.identifier.wosWOS:000302190500048
dc.language.isoeng
dc.publisherSoc Chilena Anatomia
dc.relation.ispartofInternational Journal of Morphology
dc.relation.ispartofjcr0.336
dc.relation.ispartofsjr0,207
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMuscle fiberen
dc.subjectDuchenne muscular dystrophyen
dc.subjectCitrus aurantium L.en
dc.subjectmdx mouseen
dc.subjectMuscle regenerationen
dc.subjectCentral nucleien
dc.titleEffect of Citrus aurantium l. essential oil on muscle regeneration in mdx miceen
dc.title.alternativeEfecto del aceite esencial de Citrus aurantium l. en la regeneración muscular en ratones mdxes
dc.typeArtigo
dcterms.rightsHolderSoc Chilena Anatomia
unesp.author.lattes3814504901386844[3]
unesp.author.orcid0000-0002-8645-3777[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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