Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin
dc.contributor.author | Garcia Rosa, Ana Claudia | |
dc.contributor.author | Teixeira, Lucas Novaes | |
dc.contributor.author | Passador-Santos, Fabricio | |
dc.contributor.author | Furuse, Cristiane [UNESP] | |
dc.contributor.author | Martins Montalli, Victor Angelo | |
dc.contributor.author | Araujo, Ney Soares de | |
dc.contributor.author | Araujo, Vera Cavalcanti de | |
dc.contributor.institution | Fed Univ Tocantins | |
dc.contributor.institution | Sch Med & Dent | |
dc.contributor.institution | Sao Leopoldo Mand Inst & Res Ctr | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2020-12-10T19:43:26Z | |
dc.date.available | 2020-12-10T19:43:26Z | |
dc.date.issued | 2019-12-01 | |
dc.description.abstract | Objectives This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry. Materials and methods Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopathological and immunohistochemical analysis. Sections stained for cytokeratin (K) 14, K-19, amelogenin, collagen type 1 (COL-1), and dentin matrix acidic phosphoprotein 1 (DMP-1) were evaluated using qualitative analysis. Sections stained for Ki-67 and minichromosome maintenance protein-2 (MCM-2) were evaluated using semi-quantitative analysis. Results A morphologic overlap was noticed in all BOGCL. Moreover, no differences were detected in the expression of K-14 and K-19. The expression of proliferative markers Ki-67 and MCM-2 was similar between cystic and tumor lesions (p > .05). The presence of COL-1 and absence of amelogenin in the so-called dysplastic dentin, associated with its histologic pattern, suggest that this is in fact an enameloid-like tissue. Conclusions The dysplastic dentin should be considered an enameloid-like tissue in these lesions. | en |
dc.description.affiliation | Fed Univ Tocantins, Sch Med, Quadra 109 Norte,Ave NS-15,ALCNO 14, BR-77001090 Palmas, Tocantins, Brazil | |
dc.description.affiliation | Sch Med & Dent, Fac Human & Econ & Hlth Sci ITPAC, Palmas, TO, Brazil | |
dc.description.affiliation | Sao Leopoldo Mand Inst & Res Ctr, Oral Pathol, Campinas, SP, Brazil | |
dc.description.affiliation | Sao Paulo State Univ, Pathol & Clin Propaedeut, Aracatuba, SP, Brazil | |
dc.description.affiliationUnesp | Sao Paulo State Univ, Pathol & Clin Propaedeut, Aracatuba, SP, Brazil | |
dc.format.extent | 4335-4343 | |
dc.identifier | http://dx.doi.org/10.1007/s00784-019-02863-7 | |
dc.identifier.citation | Clinical Oral Investigations. Heidelberg: Springer Heidelberg, v. 23, n. 12, p. 4335-4343, 2019. | |
dc.identifier.doi | 10.1007/s00784-019-02863-7 | |
dc.identifier.issn | 1432-6981 | |
dc.identifier.lattes | 1622189974684508 | |
dc.identifier.orcid | 0000-0002-1330-1983 | |
dc.identifier.uri | http://hdl.handle.net/11449/196396 | |
dc.identifier.wos | WOS:000501870500014 | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Clinical Oral Investigations | |
dc.source | Web of Science | |
dc.subject | Calcifying odontogenic cyst | |
dc.subject | Dentinogenic ghost cell tumor | |
dc.subject | Dentin matrix acidic phosphoprotein-1 | |
dc.subject | Collagen-1 | |
dc.subject | Amelogenin | |
dc.subject | Dysplastic dentin | |
dc.subject | Enameloid | |
dc.title | Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin | en |
dc.type | Artigo | |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Springer | |
unesp.author.lattes | 1622189974684508[4] | |
unesp.author.orcid | 0000-0002-8566-3174[1] | |
unesp.author.orcid | 0000-0003-2777-8640[3] | |
unesp.author.orcid | 0000-0002-1330-1983[4] |