Benign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentin

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dc.contributor.authorGarcia Rosa, Ana Claudia
dc.contributor.authorTeixeira, Lucas Novaes
dc.contributor.authorPassador-Santos, Fabricio
dc.contributor.authorFuruse, Cristiane [UNESP]
dc.contributor.authorMartins Montalli, Victor Angelo
dc.contributor.authorAraujo, Ney Soares de
dc.contributor.authorAraujo, Vera Cavalcanti de
dc.contributor.institutionFed Univ Tocantins
dc.contributor.institutionSch Med & Dent
dc.contributor.institutionSao Leopoldo Mand Inst & Res Ctr
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T19:43:26Z
dc.date.available2020-12-10T19:43:26Z
dc.date.issued2019-12-01
dc.description.abstractObjectives This study aimed to revisit benign odontogenic ghost cell lesions (BOGCL) by hematoxylin and eosin staining and immunohistochemistry. Materials and methods Thirty cases of calcifying odontogenic cyst (COC) and 6 cases of dentinogenic ghost cell tumor (DGCT) were selected for histopathological and immunohistochemical analysis. Sections stained for cytokeratin (K) 14, K-19, amelogenin, collagen type 1 (COL-1), and dentin matrix acidic phosphoprotein 1 (DMP-1) were evaluated using qualitative analysis. Sections stained for Ki-67 and minichromosome maintenance protein-2 (MCM-2) were evaluated using semi-quantitative analysis. Results A morphologic overlap was noticed in all BOGCL. Moreover, no differences were detected in the expression of K-14 and K-19. The expression of proliferative markers Ki-67 and MCM-2 was similar between cystic and tumor lesions (p > .05). The presence of COL-1 and absence of amelogenin in the so-called dysplastic dentin, associated with its histologic pattern, suggest that this is in fact an enameloid-like tissue. Conclusions The dysplastic dentin should be considered an enameloid-like tissue in these lesions.en
dc.description.affiliationFed Univ Tocantins, Sch Med, Quadra 109 Norte,Ave NS-15,ALCNO 14, BR-77001090 Palmas, Tocantins, Brazil
dc.description.affiliationSch Med & Dent, Fac Human & Econ & Hlth Sci ITPAC, Palmas, TO, Brazil
dc.description.affiliationSao Leopoldo Mand Inst & Res Ctr, Oral Pathol, Campinas, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Pathol & Clin Propaedeut, Aracatuba, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Pathol & Clin Propaedeut, Aracatuba, SP, Brazil
dc.format.extent4335-4343
dc.identifierhttp://dx.doi.org/10.1007/s00784-019-02863-7
dc.identifier.citationClinical Oral Investigations. Heidelberg: Springer Heidelberg, v. 23, n. 12, p. 4335-4343, 2019.
dc.identifier.doi10.1007/s00784-019-02863-7
dc.identifier.issn1432-6981
dc.identifier.lattes1622189974684508
dc.identifier.orcid0000-0002-1330-1983
dc.identifier.urihttp://hdl.handle.net/11449/196396
dc.identifier.wosWOS:000501870500014
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofClinical Oral Investigations
dc.sourceWeb of Science
dc.subjectCalcifying odontogenic cyst
dc.subjectDentinogenic ghost cell tumor
dc.subjectDentin matrix acidic phosphoprotein-1
dc.subjectCollagen-1
dc.subjectAmelogenin
dc.subjectDysplastic dentin
dc.subjectEnameloid
dc.titleBenign odontogenic ghost cell lesions revisited and new considerations on dysplastic dentinen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1622189974684508[4]
unesp.author.orcid0000-0002-8566-3174[1]
unesp.author.orcid0000-0003-2777-8640[3]
unesp.author.orcid0000-0002-1330-1983[4]

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