Effects of anaerobic training on neuromuscular junction morphology in rat diaphragm muscle

Página do item simplificado
dc.contributor.authorAguiar, A. F.
dc.contributor.authorCamaçarí De Carvalho, S. [UNESP]
dc.contributor.authorDal-Pai-Silva, M. [UNESP]
dc.contributor.authorMichelin Matheus, S. M. [UNESP]
dc.contributor.institutionNorth University of Paraná (UNOPAR)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:39:53Z
dc.date.available2018-12-11T16:39:53Z
dc.date.issued2015-01-01
dc.description.abstractAim. The purpose of this study was to test the hypothesis that anaerobic training would promote an increase in the neuromuscular junction (NMJ) diameter of diaphragm muscle in rats. Methods. Male Wistar rats were randomly assigned to either a trained (TR, N.=8) or a control (CO, N.=8) group. The trained group underwent a 5-wk anaerobic training program (5 d·wk-1; 25 sessions) using a water-jump exercise model. The CO group was not exposed to any training stimuli throughout the study. After the 5-wk experiment period, animals were euthanized and the diaphragm muscle was collected to morphometrical (diameter measurement) and ultrastructural (structural features) analysis of the NMJ Results. Anaerobic training promoted a greater increase in the NMJ diameter (+10.8%; P < 0.001) and endurance muscle (+19%; P < 0.001) of the TR group compared with the CO group. No changes (P > 0.05) in the NMJ structural features (pre- and post-synaptic components) were observed between the groups. Moreover, there was a significant positive correlation between the NMJ diameter and the muscular endurance (r = 0.72; P = 0.0001). Conclusion. Our results indicate that anaerobic training results in significant increase in diaphragm NMJ diameter, and that these morphological adaptations are well correlated with endurance exercise performance. This suggests that diaphragm muscle NMJ remodeling may play a role in fatigue.en
dc.description.affiliationCenter of Biological and Health Sciences North University of Paraná (UNOPAR), Avenue Paris, 675
dc.description.affiliationDepartment of Anatomy Cell Biology Physiology and Biophysics University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Morphology São Paulo State University (UNESP)
dc.description.affiliationDepartment of Anatomy São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Morphology São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Anatomy São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/08627-3
dc.format.extent267-274
dc.identifier.citationGazzetta Medica Italiana Archivio per le Scienze Mediche, v. 174, n. 6, p. 267-274, 2015.
dc.identifier.issn0393-3660
dc.identifier.scopus2-s2.0-84946567202
dc.identifier.urihttp://hdl.handle.net/11449/168130
dc.language.isoeng
dc.relation.ispartofGazzetta Medica Italiana Archivio per le Scienze Mediche
dc.relation.ispartofsjr0,115
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectExercise
dc.subjectFatigue
dc.subjectMotor endplate
dc.subjectPhysical endurance
dc.subjectSynapses
dc.titleEffects of anaerobic training on neuromuscular junction morphology in rat diaphragm muscleen
dc.typeArtigo

Arquivos

Coleções

Artigos