Participation of the angiotensinergic and vasopressinergic mechanisms in the maintenance of cardiorespiratory parameters in sodium depleted rats

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dc.contributor.authorCardoso, Fernanda [UNESP]
dc.contributor.authorFávero, Michele Thaís [UNESP]
dc.contributor.authorVeríssimo, Nathalia Vieira [UNESP]
dc.contributor.authorFurtado Menezes, Miguel [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorde Paula, Patricia Maria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:01:07Z
dc.date.available2023-07-29T16:01:07Z
dc.date.issued2022-12-01
dc.description.abstractChanges in blood volume can be caused by different conditions, such as vomiting, diarrhea, alteration of sodium intake, trauma, or the use of diuretics, which can lead to severe health deterioration. Understanding the mechanisms involved in the maintenance of physiological parameters and the hydroelectrolytic balance of the human body during hypovolemia, can help with preventing and handling these high-risk situations. Hence, this study investigated cardiorespiratory [mean arterial pressure (MAP), heart rate (HR), pulmonary ventilation (VE)] and blood parameters, of sodium depleted rats with furosemide and the roles of the central and peripheral renin-angiotensin and the peripheral vasopressinergic systems in controlling blood pressure in these animals. Different groups under the same conditions received subcutaneous (s.c.) injections of furosemide (diuretic/saliuretic) or vehicle, intracerebroventricular (i.c.v.) or intravenous (i.v.) injections of losartan [angiotensin II (ANG II) AT1 receptor antagonist] or saline, and i.v. injections of Manning compound (AVPX, vasopressin V1 receptor antagonist). Sodium depletion increased the VE (708 ± 71, vs. normovolemic: 478 ± 40 mL/min/kg body wt) and did not modify baseline mean arterial pressure (104 ± 4, vs. normovolemic: 105 ± 4 mmHg) and heart rate (334 ± 20, vs. normovolemic: 379 ± 13 bpm). The i.v. losartan (10 mg/kg of body wt) treatment significantly reduced MAP in all groups and elevated HR, with a greater impact in sodium depleted rats before repletion. On the other hand, the i.c.v. losartan (3.3 μg/kg of body wt) and i.v. AVPX (10 μg/kg of body wt) treatments did not alter the MAP and HR in control, sodium depleted, and sodium repleted rats. These results indicate that sodium depletion affects cardiorespiratory control increasing baseline ventilation and peripheral angiotensinergic mechanisms are relevant for maintaining cardiovascular parameters in sodium depleted rats. Besides, this study suggests vasopressin V1 receptors do not participate in the maintenance of MAP and HR in sodium depleted animals with furosemide.en
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry São Paulo State University - UNESP, SP
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry São Paulo State University - UNESP, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2007/50647-0
dc.identifierhttp://dx.doi.org/10.1016/j.heliyon.2022.e12221
dc.identifier.citationHeliyon, v. 8, n. 12, 2022.
dc.identifier.doi10.1016/j.heliyon.2022.e12221
dc.identifier.issn2405-8440
dc.identifier.scopus2-s2.0-85144441897
dc.identifier.urihttp://hdl.handle.net/11449/249492
dc.language.isoeng
dc.relation.ispartofHeliyon
dc.sourceScopus
dc.subjectAngiotensin II
dc.subjectCentral and peripheral cardiovascular regulation
dc.subjectFurosemide
dc.subjectSodium depletion
dc.subjectVasopressin
dc.subjectVentilation
dc.titleParticipation of the angiotensinergic and vasopressinergic mechanisms in the maintenance of cardiorespiratory parameters in sodium depleted ratsen
dc.typeArtigo
unesp.author.orcid0000-0003-3351-5118[1]

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