Chemiluminescence as a PDT light source for microbial control

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dc.contributor.authorFerraz, Ruy C. M. C.
dc.contributor.authorFontana, Carla R.
dc.contributor.authorde Ribeiro, Ana P. [UNESP]
dc.contributor.authorTrindade, Flavia Z. [UNESP]
dc.contributor.authorBartoloni, Fernando H.
dc.contributor.authorBaader, Josef W.
dc.contributor.authorLins, Emery C.
dc.contributor.authorBagnato, Vanderlei S.
dc.contributor.authorKurachi, Cristina
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2014-05-20T15:32:33Z
dc.date.available2014-05-20T15:32:33Z
dc.date.issued2011-05-03
dc.description.abstractThe photodynamic therapy (PDT) is a combination of using a photosensitizer agent, light and oxygen that can cause oxidative cellular damage. This technique is applied in several cases, including for microbial control. The most extensively studied light sources for this purpose are lasers and LED-based systems. Few studies treat alternative light sources based PDT. Sources which present flexibility, portability and economic advantages are of great interest. In this study, we evaluated the in vitro feasibility for the use of chemiluminescence as a PDT light source to induce Staphylococcus aureus reduction. The Photogem (R) concentration varied from 0 to 75 mu g/ml and the illumination time varied from 60 min to 240 min. The long exposure time was necessary due to the low irradiance achieved with chemiluminescence reaction at mu W/cm(2) level. The results demonstrated an effective microbial reduction of around 98% for the highest photosensitizer concentration and light dose. These data suggest the potential use of chemiluminescence as a light source for PDT microbial control, with advantages in terms of flexibility, when compared with conventional sources. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Phys São Carlos, BR-13560970 São Carlos, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Coll Dent Araraquara, Araraquara, Brazil
dc.description.affiliationUniv São Paulo, Inst Chem, USP, BR-13560970 São Carlos, SP, Brazil
dc.description.affiliationFed Univ ABC, UFABC, CECS, Santo Andre, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Coll Dent Araraquara, Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent87-92
dc.identifierhttp://dx.doi.org/10.1016/j.jphotobiol.2011.01.018
dc.identifier.citationJournal of Photochemistry and Photobiology B-biology. Lausanne: Elsevier B.V. Sa, v. 103, n. 2, p. 87-92, 2011.
dc.identifier.doi10.1016/j.jphotobiol.2011.01.018
dc.identifier.issn1011-1344
dc.identifier.urihttp://hdl.handle.net/11449/41419
dc.identifier.wosWOS:000290069500001
dc.language.isoeng
dc.publisherElsevier B.V. Sa
dc.relation.ispartofJournal of Photochemistry and Photobiology B: Biology
dc.relation.ispartofjcr3.165
dc.relation.ispartofsjr0,698
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPhotodynamic therapyen
dc.subjectChemiluminescenceen
dc.subjectMicrobial controlen
dc.subjectLow intensity irradiationen
dc.titleChemiluminescence as a PDT light source for microbial controlen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V. Sa
unesp.author.lattes5168319315634298[2]
unesp.author.orcid0000-0002-7967-6163[7]
unesp.author.orcid0000-0002-9135-3690[2]
unesp.author.orcid0000-0001-7678-8576[6]
unesp.author.orcid0000-0003-3185-7640[4]

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