Single intraoperative infrared laser optimized bone repair in rat femoral osteotomies with experimentally induced osteoporosis

Página do item simplificado
dc.contributor.authorPolo, Tárik Ocon Braga [UNESP]
dc.contributor.authorFonseca-Santos, João Matheus [UNESP]
dc.contributor.authorMomesso, Gustavo Antonio Correa [UNESP]
dc.contributor.authorda Silva, William Phillip Pereira [UNESP]
dc.contributor.authorBarbosa, Stefany [UNESP]
dc.contributor.authorSantos, Anderson Maikon de Souza [UNESP]
dc.contributor.authorSilva, Mirela Caroline [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.authorFaverani, Leonardo P. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Santo Amaro
dc.date.accessioned2023-07-29T16:09:03Z
dc.date.available2023-07-29T16:09:03Z
dc.date.issued2023-12-01
dc.description.abstractThis study aimed to evaluate the effect of infrared laser (IRL) on bone repair in ovariectomized rats subjected to femoral osteotomies. Of 32 rats, half underwent bilateral ovariectomy (OVX) and the other half underwent sham ovariectomy (SHAM). A period of 3 months was defined to observe the presence of osteoporosis. The rats were subjected to osteotomies in the femurs and then fixed with a miniplate and 1.5-mm system screws. Thereafter, half of the rats from both SHAM and OVX groups were not irradiated, and the other half were irradiated by IRL using the following parameters: wavelength, 808 nm; power, 100 mW; 60 s for each point; 6 J/point; and a total of 5 points of bone gap. All animals were euthanized 60 days after surgery. The femur gap was scanned using micro-computed tomography (micro-CT). The samples were then examined under a confocal laser microscope to determine the amounts of calcein and alizarin red. The slides were stained with alizarin red and Stevenel’s blue for histometric analysis. In the micro-CT analysis, the OVX groups had the lowest bone volume (P < 0.05). When the laser was applied to the OVX groups, bone turnover increased (P < 0.05). New bone formation (NBF) was comparable between SHAM and OVX/IR (P > 0.05) groups; however, it was less in the OVX groups (P < 0.05). In conclusion, the results encourage the use of IRL intraoperatively as it optimizes bone repair, mainly in animals with low bone mineral density.en
dc.description.affiliationSchool of Dentistry São Paulo State University (UNESP), São Paulo
dc.description.affiliationDepartment of Implantology University of Santo Amaro, Unisa, SP
dc.description.affiliationDiagnosis and Surgery Department School of Dentistry São Paulo State University (UNESP), 1193 José Bonifácio Street, São Paulo
dc.description.affiliationUnespSchool of Dentistry São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespDiagnosis and Surgery Department School of Dentistry São Paulo State University (UNESP), 1193 José Bonifácio Street, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2016/20297-6
dc.description.sponsorshipIdFAPESP: 2018/11496-0
dc.identifierhttp://dx.doi.org/10.1007/s10103-023-03746-w
dc.identifier.citationLasers in Medical Science, v. 38, n. 1, 2023.
dc.identifier.doi10.1007/s10103-023-03746-w
dc.identifier.issn1435-604X
dc.identifier.issn0268-8921
dc.identifier.scopus2-s2.0-85150531570
dc.identifier.urihttp://hdl.handle.net/11449/249782
dc.language.isoeng
dc.relation.ispartofLasers in Medical Science
dc.sourceScopus
dc.subjectBone regeneration
dc.subjectFracture fixation internal
dc.subjectLaser therapy
dc.subjectOsteoporosis
dc.titleSingle intraoperative infrared laser optimized bone repair in rat femoral osteotomies with experimentally induced osteoporosisen
dc.typeArtigo
unesp.author.orcid0000-0003-0364-6344[1]
unesp.author.orcid0000-0002-2021-778X[2]
unesp.author.orcid0000-0003-4529-683X[3]
unesp.author.orcid0000-0003-4172-7217[4]
unesp.author.orcid0000-0002-4190-7931[5]
unesp.author.orcid0000-0001-9371-9417[6]
unesp.author.orcid0000-0002-9455-3807[7]
unesp.author.orcid0000-0002-6715-8334[8]
unesp.author.orcid0000-0003-3026-8369[9]
unesp.author.orcid0000-0003-2249-3048[10]

Arquivos

Coleções

Artigos - Cirurgia e Clínica Integrada - FOA