Extraction-assisted voltammetric determination of homocysteine using magnetic nanoparticles modified with molecularly imprinted polymer

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dc.contributor.authorda Conceição, Poliana
dc.contributor.authordos Santos Neto, Antonio Gomes
dc.contributor.authorKhan, Sabir [UNESP]
dc.contributor.authorTanaka, Auro A.
dc.contributor.authorSantana, Antônio Euzébio G.
dc.contributor.authordel Pilar Taboada-Sotomayor, Maria [UNESP]
dc.contributor.authorGoulart, Marília O. F.
dc.contributor.authorSantos, Ana Caroline Ferreira
dc.contributor.institutionUniversidade Federal de Alagoas
dc.contributor.institutionAvenida dos Portugueses
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionNational Institute of Science and Technology of Bioanalytics (INCT-Bio)
dc.date.accessioned2023-07-29T12:57:42Z
dc.date.available2023-07-29T12:57:42Z
dc.date.issued2023-04-01
dc.description.abstractA magnetic graphite-epoxy composite (m-GEC) electrochemical sensor is presented based on magnetic imprinted polymer (mag-MIP) to determine homocysteine (Hcy). Mag-MIP was synthesized via precipitation polymerization, using functionalized magnetic nanoparticles (Fe3O4) together with the template molecule (Hcy), the functional monomer 2-hydroxyethyl methacrylate (HEMA), and the structural monomer trimethylolpropane trimethacrylate (TRIM). For mag-NIP (magnetic non-imprinted polymer), the procedure was the same in the absence of Hcy. Morphological and structural properties of the resultant mag-MIP and mag-NIP were examined using TEM, FT-IR, and Vibrating Sample Magnetometer. Under optimized conditions, the m-GEC/mag-MIP sensor showed a linear range of 0.1–2 µmol L−1, with a limit of detection (LOD) of 0.030 µmol L−1. In addition, the proposed sensor responded selectively to Hcy compared to several interferents present in biological samples. The recovery values determined by differential pulse voltammetry (DPV) were close to 100% for natural and synthetic samples, indicating good method accuracy. The developed electrochemical sensor proves to be a suitable device for determining Hcy, with advantages related to magnetic separation and electrochemical analysis.en
dc.description.affiliationPrograma de Pós-graduação em Química e Biotecnologia (PPGQB) Instituto de Química e Biotecnologia Universidade Federal de Alagoas, Campus A.C. Simões, Tabuleiro dos Martins, AL
dc.description.affiliationDepartamento de Química Universidade Federal do Maranhão Avenida dos Portugueses, MA
dc.description.affiliationInstituto de Química INCT-DATREM Universidade Estadual Paulista, Rua Prof. Francisco Degni, 55, SP
dc.description.affiliationNational Institute of Science and Technology of Bioanalytics (INCT-Bio)
dc.description.affiliationUnespInstituto de Química INCT-DATREM Universidade Estadual Paulista, Rua Prof. Francisco Degni, 55, SP
dc.identifierhttp://dx.doi.org/10.1007/s00604-023-05738-7
dc.identifier.citationMicrochimica Acta, v. 190, n. 4, 2023.
dc.identifier.doi10.1007/s00604-023-05738-7
dc.identifier.issn1436-5073
dc.identifier.issn0026-3672
dc.identifier.scopus2-s2.0-85150956061
dc.identifier.urihttp://hdl.handle.net/11449/247052
dc.language.isoeng
dc.relation.ispartofMicrochimica Acta
dc.sourceScopus
dc.subjectDifferential pulse voltammetry
dc.subjectElectroanalysis
dc.subjectElectrochemical sensor
dc.subjectFe3O4 nanoparticles
dc.subjectHyperhomocysteinemia
dc.subjectMagnetic molecularly imprinted polymer
dc.titleExtraction-assisted voltammetric determination of homocysteine using magnetic nanoparticles modified with molecularly imprinted polymeren
dc.typeArtigo
unesp.author.orcid0000-0001-9155-8568[1]
unesp.author.orcid0000-0003-3345-2866[2]
unesp.author.orcid0000-0003-4557-238X[3]
unesp.author.orcid0000-0001-5299-2505[4]
unesp.author.orcid0000-0001-5025-9107[5]
unesp.author.orcid0000-0002-6173-7888[6]
unesp.author.orcid0000-0001-9860-3667[7]
unesp.author.orcid0000-0001-7666-5859[8]

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