The role of qualea multiflora on mammary tumour cells and immune system

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dc.contributor.authorCarli, Camila Bernardes de Andrade
dc.contributor.authorQuilles, Marcela Bassi
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:16Z
dc.date.available2016-01-28T16:56:16Z
dc.date.issued2013
dc.description.abstractSpecies of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-a) and the transcription factor NF-κB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-a; about 32% of NF-κB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.format.extent8-13
dc.identifierhttp://connection.ebscohost.com/c/articles/91744910/role-qualea-multiflora-mammary-tumour-cells-immune-system
dc.identifier.citationJournal of Applied Pharmaceutical Science, v. 3, n. 9, p. 8-13, 2013.
dc.identifier.issn2231-3354
dc.identifier.lattes1730146818754269
dc.identifier.lattes7927877224326837
dc.identifier.lattes2475607853580549
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/133707
dc.language.isoeng
dc.relation.ispartofJournal of Applied Pharmaceutical Science
dc.relation.ispartofsjr0,244
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleThe role of qualea multiflora on mammary tumour cells and immune systemen
dc.typeArtigo
unesp.author.lattes1730146818754269
unesp.author.lattes7927877224326837
unesp.author.lattes2475607853580549
unesp.author.orcid0000-0003-3032-2556[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicaspt

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