Reliability of carnitine concentrations measured in single postprandial urine samples from dogs

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Objective - To evaluate the reliability of urine carnitine concentrations measured in single postprandial samples, compared with carnitine concentrations measured in 24-hour urine samples. Animals - 19 healthy Beagles. Procedure - After emptying the urinary bladder by catheterization, dogs were fed a canned canine maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of urinary carnitine fractional excretion and urine carnitine-to-creatinine concentration ratio. Results were compared with 24-hour urinary carnitine excretion rate. Results - Fractional excretion of carnitine and urine carnitine-to-creatinine ratios correlated poorly with 24-hour urinary carnitine excretion. Conclusion - Determination of 24-hour urinary carnitine excretion is recommended to measure urine carnitine concentrations in dogs.



biological marker, carnitine, animal, animal food, blood, comparative study, dog, female, male, orchiectomy, ovariectomy, postprandial state, reference value, reproducibility, urine, Animal Nutrition Physiology, Animals, Biological Markers, Carnitine, Dogs, Female, Male, Orchiectomy, Ovariectomy, Postprandial Period, Reference Values, Reproducibility of Results

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American Journal of Veterinary Research, v. 57, n. 8, p. 1185-1188, 1996.