Preoperative vitamin D level as a post-total thyroidectomy hypocalcemia predictor: a prospective study

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dc.contributor.authorSoares, Carlos Segundo Paiva [UNESP]
dc.contributor.authorTagliarini, José Vicente [UNESP]
dc.contributor.authorMazeto, Gláucia M.F.S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:45:20Z
dc.date.available2019-10-06T16:45:20Z
dc.date.issued2019-01-01
dc.description.abstractIntroduction: Hypocalcemia is one of the most common complications after total thyroidectomy. Preoperative serum vitamin D concentration has been postulated as a risk factor for this complication. However, the subject is still controversial and the role of vitamin D in the occurrence of hypocalcemia remains uncertain. Objective: To evaluate the capability of preoperative vitamin D concentrations in predicting post-total thyroidectomy hypocalcemia. Methods: Forty-seven total thyroidectomy patients were prospectively evaluated for serum 25(OH) vitamin D, calcium and parathyroid hormone before surgery, Calcium every 6 h, and parathyroid hormone 8 h post-operatively. Patients were divided according to postoperative corrected calcium into groups without (corrected calcium ≥8.5 mg/dL) and with hypocalcemia (corrected calcium <8.5 mg/dL), who were then evaluated for preoperative 25(OH) vitamin D values. Results: A total of 72.3% of cases presented altered 25(OH) vitamin D preoperative serum concentrations and 51% evolved with postoperative hypocalcemia. The with and without hypocalcemia groups did not differ for preoperative 25(OH) vitamin D (p = 0.62). Univariate analysis showed that age (p = 0.03), postoperative PTH concentration (p = 0.02), and anatomopathological diagnosis of malignancy (p = 0.002) were predictors of postoperative hypocalcemia. In multivariate analysis only parathyroid hormone in postoperative (p = 0.02) was associated with post-total thyroidectomy hypocalcemia. Conclusion: Preoperative serum concentrations of 25(OH) vitamin D were not predictors for post-total thyroidectomy hypocalcemia, whereas postoperative parathyroid hormone influenced the occurrence of this complication.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Medicina Interna
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Medicina Interna
dc.identifierhttp://dx.doi.org/10.1016/j.bjorl.2019.07.001
dc.identifier.citationBrazilian Journal of Otorhinolaryngology.
dc.identifier.doi10.1016/j.bjorl.2019.07.001
dc.identifier.fileS1808-86942021000100085.pdf
dc.identifier.issn1808-8686
dc.identifier.issn1808-8694
dc.identifier.scieloS1808-86942021000100085
dc.identifier.scopus2-s2.0-85071532278
dc.identifier.urihttp://hdl.handle.net/11449/189582
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectParathyroid hormone
dc.subjectThyroidectomy
dc.subjectVitamin D
dc.titlePreoperative vitamin D level as a post-total thyroidectomy hypocalcemia predictor: a prospective studyen
dc.titleNível pré-operatório de vitamina D como preditor de hipocalcemia pós-tireoidectomia total: estudo prospectivopt
dc.typeArtigo
unesp.author.orcid0000-0003-0121-9533[1]
unesp.author.orcid0000-0002-0869-724X[2]
unesp.author.orcid0000-0003-2129-7256[3]

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