Effects of quercetin administration on the pregnancy outcome of diabetic rats

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dc.contributor.authorBraga, Camila Pereira [UNESP]
dc.contributor.authorBaptista, Rafaela de Fátima Ferreira [UNESP]
dc.contributor.authorPeixoto, Fernando Barbosa [UNESP]
dc.contributor.authorMomentti, Ana Carolina [UNESP]
dc.contributor.authorFava, Fábio Henrique [UNESP]
dc.contributor.authorFernandes, Ana Angélica Henrique [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-04-01T18:44:59Z
dc.date.available2016-04-01T18:44:59Z
dc.date.issued2012
dc.description.abstractObjective: Investigate the effects of diabetes and treatment with quercetin on the maternal reproductive performance and impact on foetal growth. Study design: A total of 32 female Wistar rats were distributed into four groups: non-diabetic (G1); non-diabetic treated with quercetin (G2); diabetic (G3) and diabetic treated with quercetin (G4). At day 21 of pregnancy, each rat was anesthetized and humanely killed for laparotomy; was observed reproductive performance, foetal and placental weights and the placental index. Maternal and foetal data were analysed by ANOVA followed by the Tukey test. Foetal weight classification was assessed by Goodman’s test. Results: Diabetes and diabetes treated with quercetin caused placentomegaly an increased placental index and small foetus rates for pregnancy age. Conclusion: Quercetin, administered to pregnant diabetic rats, controlled glucose levels and promoted weight gain compared to untreated diabetic rats, but it did not improve reproductive performance or foetal or placental development.en
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Química e Bioquímica, Instituto de Biociências de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Farmacologia, Instituto de Biociências de Botucatu
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1-4
dc.identifierhttp://dx.doi.org/10.4172/2155-6156.1000180
dc.identifier.citationJournal of Diabetes & Metabolism, v. 3, n. 2, p. 1-4, 2012.
dc.identifier.doi10.4172/2155-6156.1000180
dc.identifier.issn2155-6156
dc.identifier.urihttp://hdl.handle.net/11449/137277
dc.language.isoeng
dc.relation.ispartofJournal of Diabetes & Metabolism
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectDiabetes mellitusen
dc.subjectFoetusen
dc.subjectPlacentaen
dc.subjectPregnancyen
dc.subjectQuercetinen
dc.titleEffects of quercetin administration on the pregnancy outcome of diabetic ratsen
dc.typeArtigo
unesp.author.lattes0077247086732148[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentQuímica e Bioquímicapt
unesp.departmentFarmacologiapt

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Artigos - Química e Bioquímica - IBB
Artigos - Farmacologia - IBB