Publicação:
Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice

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dc.contributor.authorDos Santos, Amanda R. [UNESP]
dc.contributor.authorFraga-Silva, Thais F. [UNESP]
dc.contributor.authorAlmeida, Débora de F [UNESP]
dc.contributor.authorDos Santos, Rodolfo F. [UNESP]
dc.contributor.authorFinato, Angela C. [UNESP]
dc.contributor.authorAmorim, Bárbara C [UNESP]
dc.contributor.authorAndrade, Maria I.
dc.contributor.authorSoares, Cleverson T.
dc.contributor.authorLara, Vanessa S.
dc.contributor.authorAlmeida, Nara Lm
dc.contributor.authorde Arruda, Olavo S. [UNESP]
dc.contributor.authorde Arruda, Maria Sp [UNESP]
dc.contributor.authorVenturini, James [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLauro de Souza Lima Institute
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2020-12-12T01:34:40Z
dc.date.available2020-12-12T01:34:40Z
dc.date.issued2020-06-01
dc.description.abstractAim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae.en
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Faculdade de Ciências
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Instituto de Biociências
dc.description.affiliationLauro de Souza Lima Institute
dc.description.affiliationUniversidade de São Paulo (USP), Faculdade de Odontologia de Bauru (FOB)
dc.description.affiliationUniversidade Federal de Mato Grosso do Sul (UFMS) Faculdade de Medicina
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Faculdade de Ciências
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Instituto de Biociências
dc.format.extent739-752
dc.identifierhttp://dx.doi.org/10.2217/fmb-2019-0246
dc.identifier.citationFuture microbiology, v. 15, p. 739-752.
dc.identifier.doi10.2217/fmb-2019-0246
dc.identifier.issn1746-0921
dc.identifier.scopus2-s2.0-85089301353
dc.identifier.urihttp://hdl.handle.net/11449/199246
dc.language.isoeng
dc.relation.ispartofFuture microbiology
dc.sourceScopus
dc.subjectBALB/c
dc.subjectC57BL/6
dc.subjectcytokines
dc.subjectIL-17
dc.subjectIl17ra-/-
dc.subjectil6
dc.subjectimmunocompetent model
dc.subjectintravenous infection
dc.subjectmucormycosis
dc.subjectRhizopus oryzae
dc.subjectrorc
dc.subjectSwiss
dc.titleRhizopus-host interplay of disseminated mucormycosis in immunocompetent miceen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-5269-6084[1]
unesp.author.orcid0000-0002-2053-8938[2]
unesp.author.orcid0000-0002-9184-3868[6]
unesp.author.orcid0000-0002-1286-5410[8]
unesp.author.orcid0000-0003-1986-0003[9]
unesp.author.orcid0000-0001-7039-1551[10]
unesp.author.orcid0000-0002-1828-4270[12]
unesp.author.orcid0000-0003-0035-2439 0000-0003-0035-2439[13]

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