Isolation and molecular characterization of Brazilian turkey reovirus from immunosuppressed young poults

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Rosa, Ana Carolina G. [UNESP]
Ferreira, Helena Lage
Gomes, Deriane Elias [UNESP]
Táparo, Cilene Vidovix [UNESP]
Cardoso, Tereza Cristina [UNESP]

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In this study, we investigated turkey reovirus (TReoV) in tissue samples from young birds, aged 15 days. RT-PCR for TReoV detected 3.3 % positive samples and TReoV was successfully isolated in Vero cells. Histological analysis of positive bursa of Fabricius (BF) revealed atrophied follicles and lymphocyte depletion. The number of CD8+, CD4+ and IgM+ cells was lower in infected BF. Phylogenetic analysis based on S3 gene showed that the Brazilian TReoV isolates clustered in a single group with 98-100 % similarity to TReoV strains circulating in the United States. This is the first indication that TReoV infection may be a contributing factor to immunosuppression in young birds.



Virology, Medical microbiology, Infectious diseases

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Archives of Virology, v. 159, p. 1453-1457, 2013.