Publicação:
Interpreting histopathology in the epididymis

dc.contributor.authorKempinas, Wilma De Grava [UNESP]
dc.contributor.authorKlinefelter, Gary Robert
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUS Environmental Protection Agency
dc.date.accessioned2015-12-07T15:30:42Z
dc.date.available2015-12-07T15:30:42Z
dc.date.issued2014
dc.description.abstractWhile most of this Special Issue is devoted to the testis (which is where most drug and chemically induced toxicity of the male reproductive tract is identified), being able to recognize and understand the potential effects of toxicants on the epididymis is immensely important and an area that is often overlooked. The epididymis is the organ where the post-testicular sperm differentiation occurs, through a complex and still not completely understood sperm maturation process, allowing them to fertilize the oocyte. Also in the epididymis, sperm are stored until ejaculation, while being protected from immunogenic reaction by a blood-epididymis barrier. From a toxicologic perspective the epididymis is inherently complicated as its structure and function can be altered both indirectly and directly. In this review we will discuss the factors that must be considered when attempting to distinguish between indirect and direct epididymal toxicity and highlight what is currently known about mechanisms of epididymal toxicants, using the rat as a reference model. We identify 2 distinguishable signature lesions - one representing androgen deprivation (secondary to Leydig cell toxicity in the testis) and another representing a direct acting toxicant. Other commonly observed alterations will also be shown and discussed. Finally, we point out that many of the key functions of the epididymis can be altered in the absence of a detectable change in tissue structure. Collectively, we hope this will provide pathologists with increased confidence in identification of epididymal toxicity and enable more informed guidance as mechanism of action is considered.en
dc.description.affiliationUS Environmental Protection Agency, National Health and Environmental Research Laboratory, Reproductive Toxicology Division
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Morfologia, Instituto de Biociências de Botucatu
dc.format.extent1-12
dc.identifierhttp://dx.doi.org/10.4161/21565562.2014.979114
dc.identifier.citationSpermatogenesis, v. 4, n. 2, p. 1-12, 2014.
dc.identifier.doi10.4161/21565562.2014.979114
dc.identifier.issn2156-5554
dc.identifier.lattes6326450271169741
dc.identifier.pmcPMC4581052
dc.identifier.pubmed26413396
dc.identifier.urihttp://hdl.handle.net/11449/130996
dc.language.isoeng
dc.relation.ispartofSpermatogenesis
dc.relation.ispartofsjr0,128
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAndrogenen
dc.subjectEpididymisen
dc.subjectHistopathologyen
dc.subjectSperm maturationen
dc.subjectToxicityen
dc.titleInterpreting histopathology in the epididymisen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes6326450271169741
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

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