Impact of probiotic and prebiotic on gut microbiota in pre-diabetes and type 2 diabetes

Página do item simplificado
dc.contributor.authorRamos, Fernanda Maria Manzini [UNESP]
dc.contributor.authorSalgaço, Mateus Kawata [UNESP]
dc.contributor.authorCesar, Thais [UNESP]
dc.contributor.authorSivieri, Katia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:52:54Z
dc.date.available2023-07-29T13:52:54Z
dc.date.issued2022-03-08
dc.description.abstractThe increased worldwide prevalence of pre-diabetes and diabetes, especially type 2 diabetes, requiring different strategies for their prevention and management. A new focus is the reversal of diabetes dysbiosis, a disruption of gut microbiota homeostasis, which is closely related to elevated blood glucose levels and altered metabolic parameters. In this sense, a balanced diet plays a key role, and, particularly, probiotic and prebiotic have shown a promising role. This chapter explored current knowledge on the potential of probiotic and prebiotic to modulate glucose homeostasis. We showed that the consumption of probiotics and prebiotics is a promising strategy with a beneficial impact on gut microbiota and glycemic control. Furthermore, specific probiotic strains, such as L. acidophilus, L. casei strain Shirota, and B. lactis Bb12, have demonstrated the ability to improve parameters related to pre-diabetes and type 2 diabetes. In addition, polyphenols are emerging as a new alternative in glycemic control through the production of short chain fat acids (SCFA) and decreased lipopolysaccharides (LPS) translocation that leads to metabolic endotoxemia. Finally, the ingestion of beneficial bacteria, and foods rich in fiber and polyphenols, or a combination of them, is a good strategy for the control of pre-diabetes and type 2 diabetes, but more studies are still needed, mainly clinical trials, for these strategies are improved and widely used.en
dc.description.affiliationDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.format.extent77-100
dc.identifierhttp://dx.doi.org/10.1007/978-3-030-92196-5_3
dc.identifier.citationNatural Products in Obesity and Diabetes: Therapeutic Potential and Role in Prevention and Treatment, p. 77-100.
dc.identifier.doi10.1007/978-3-030-92196-5_3
dc.identifier.scopus2-s2.0-85154578047
dc.identifier.urihttp://hdl.handle.net/11449/248757
dc.language.isoeng
dc.relation.ispartofNatural Products in Obesity and Diabetes: Therapeutic Potential and Role in Prevention and Treatment
dc.sourceScopus
dc.titleImpact of probiotic and prebiotic on gut microbiota in pre-diabetes and type 2 diabetesen
dc.typeCapítulo de livro
unesp.departmentAlimentos e Nutrição - FCFpt

Arquivos

Coleções

Araraquara - FCF - Faculdade de Ciências Farmacêuticas