Natural Products from Cyanobacteria with Antimicrobial and Antitumor Activity

dc.contributor.authorSilva-Stenico, Maria Estela
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.authorZambuzi, Fabiana Albani [UNESP]
dc.contributor.authorVaz, Marcelo G. M. V.
dc.contributor.authorAlvarenga, Danillo O.
dc.contributor.authorFiore, Marli Fatima
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.abstractCyanobacteria are an important source of structurally bioactive metabolites, with cytotoxic, antiviral, anticancer, antimitotic, antimicrobial, specific enzyme inhibition and immunosuppressive activities. This study focused on the antitumor and antimicrobial activities of intra and extracellular cyanobacterial extracts. A total of 411 cyanobacterial strains were screened for antimicrobial activity using a subset of pathogenic bacteria as target. The in vitro antitumor assays were performed with extracts of 24 strains tested against two murine cancer cell lines (colon carcinoma CT-26 and lung cancer 3LL). Intracellular extracts inhibited 49 and 35% of Gram-negative and Gram-positive pathogenic bacterial growth, respectively. Furthermore, the methanolic intracellular extract of Cylindrospermopsis raciborskii CYP011K and Nostoc sp. CENA69 showed inhibitory activity against the cancer cell lines. The extracellular extract from Fischerella sp. CENA213 and M. aeruginosa NPJB-1 exhibited inhibitory activity against 3LL lung cancer cells at 0.8 mu g ml(-1) and Oxynema sp. CENA135, Cyanobium sp. CENA154, M. aeruginosa NPJB-1 and M. aeruginosa NPLJ-4 presented inhibitory activity against CT26 colon cancer cells at 0.8 mu g ml(-1). Other extracts were able to inhibit 3LL cell-growth at higher concentrations (20 mu g ml(-1)) such as Nostoc sp. CENA67, Cyanobium sp. CENA154 and M. aeruginosa NPLJ-4, while CT26 cells were inhibited at the same concentration by Nostoc sp. CENA67 and Fischerella sp. CENA213. These extracts presented very low inhibitory activity on human peripheral blood lymphocytes. The results showed that some cyanobacterial strains are a rich source of natural products with potential for pharmacological and biotechnological applications.en
dc.description.affiliationUniv Sao Paulo, Ctr Nucl Energy Agr, Mol Ecol Cyanobacteria Lab, BR-13400970 Piracicaba, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Microbiol & Immunol, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Microbiol & Immunol, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBrazilian National Research Council
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 09/05474-5
dc.description.sponsorshipIdFAPESP: 10/09867-9
dc.description.sponsorshipIdFAPESP: 10/18732-0
dc.description.sponsorshipIdFAPESP: 11/08092-6
dc.description.sponsorshipIdFAPESP: 11/20307-8
dc.description.sponsorshipIdCNPq: 559720/2009-2
dc.description.sponsorshipIdCNPq: 308299/2009-4
dc.description.sponsorshipIdCNPq: 303952/2010-5
dc.description.sponsorshipIdCNPq: 151931/2010-0
dc.identifier.citationCurrent Pharmaceutical Biotechnology. Sharjah: Bentham Science Publ Ltd, v. 14, n. 9, p. 820-828, 2013.
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Biotechnology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntiproliferative activityen
dc.subjectNatural productsen
dc.subjectTumor cell linesen
dc.titleNatural Products from Cyanobacteria with Antimicrobial and Antitumor Activityen
dcterms.rightsHolderBentham Science Publ Ltd[2][2][6][5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt