Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
dc.contributor.author | Megid, Jane [UNESP] | |
dc.contributor.author | Benavides Tala, Julio Andre [UNESP] | |
dc.contributor.author | Belaz Silva, Laís Dário [UNESP] | |
dc.contributor.author | Castro Castro, Fernando Favian [UNESP] | |
dc.contributor.author | Ribeiro, Bruna Letícia Devidé [UNESP] | |
dc.contributor.author | Appolinário, Camila Michele [UNESP] | |
dc.contributor.author | Katz, Iana Suly Santos | |
dc.contributor.author | Scheffer, Karin Corrêa | |
dc.contributor.author | Silva, Sandriana Ramos | |
dc.contributor.author | Rosa, Adriana Ruckert | |
dc.contributor.author | Barone, Gisely Toledo | |
dc.contributor.author | Alves Martorelli, Luzia Fátima | |
dc.contributor.author | de Almeida, Marilene Fernandes | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidad Andrés Bello | |
dc.contributor.institution | Universidad Antonio Narino Cauca Popayan | |
dc.contributor.institution | Immunology Laboratory Pasteur Institute of São Paulo | |
dc.contributor.institution | Coordenadoria de vigilância em saúde | |
dc.date.accessioned | 2022-04-29T08:46:00Z | |
dc.date.available | 2022-04-29T08:46:00Z | |
dc.date.issued | 2021-09-29 | |
dc.description.abstract | The control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human. | en |
dc.description.affiliation | School of Veterinary Medicine and Animal Science São Paulo State University (Unesp) | |
dc.description.affiliation | Centro de Investigación para la sustestabilidad Facultad de Ciencias de la vida Universidad Andrés Bello | |
dc.description.affiliation | Animal Health Department Universidad Antonio Narino Cauca Popayan | |
dc.description.affiliation | Diagnostics Sector Immunology Laboratory Pasteur Institute of São Paulo | |
dc.description.affiliation | Centro de Controle de Zoonoses Coordenadoria de vigilância em saúde | |
dc.description.affiliationUnesp | School of Veterinary Medicine and Animal Science São Paulo State University (Unesp) | |
dc.identifier | http://dx.doi.org/10.3389/fvets.2021.681423 | |
dc.identifier.citation | Frontiers in Veterinary Science, v. 8. | |
dc.identifier.doi | 10.3389/fvets.2021.681423 | |
dc.identifier.issn | 2297-1769 | |
dc.identifier.scopus | 2-s2.0-85117140162 | |
dc.identifier.uri | http://hdl.handle.net/11449/231532 | |
dc.language.iso | eng | |
dc.relation.ispartof | Frontiers in Veterinary Science | |
dc.source | Scopus | |
dc.subject | antibodies | |
dc.subject | rabies | |
dc.subject | RFFIT | |
dc.subject | serology | |
dc.subject | vampire bats | |
dc.subject | virus neutralizing antibodies | |
dc.title | Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus | en |
dc.type | Artigo |