Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus

Página do item simplificado
dc.contributor.authorMegid, Jane [UNESP]
dc.contributor.authorBenavides Tala, Julio Andre [UNESP]
dc.contributor.authorBelaz Silva, Laís Dário [UNESP]
dc.contributor.authorCastro Castro, Fernando Favian [UNESP]
dc.contributor.authorRibeiro, Bruna Letícia Devidé [UNESP]
dc.contributor.authorAppolinário, Camila Michele [UNESP]
dc.contributor.authorKatz, Iana Suly Santos
dc.contributor.authorScheffer, Karin Corrêa
dc.contributor.authorSilva, Sandriana Ramos
dc.contributor.authorRosa, Adriana Ruckert
dc.contributor.authorBarone, Gisely Toledo
dc.contributor.authorAlves Martorelli, Luzia Fátima
dc.contributor.authorde Almeida, Marilene Fernandes
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidad Andrés Bello
dc.contributor.institutionUniversidad Antonio Narino Cauca Popayan
dc.contributor.institutionImmunology Laboratory Pasteur Institute of São Paulo
dc.contributor.institutionCoordenadoria de vigilância em saúde
dc.date.accessioned2022-04-29T08:46:00Z
dc.date.available2022-04-29T08:46:00Z
dc.date.issued2021-09-29
dc.description.abstractThe control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human.en
dc.description.affiliationSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp)
dc.description.affiliationCentro de Investigación para la sustestabilidad Facultad de Ciencias de la vida Universidad Andrés Bello
dc.description.affiliationAnimal Health Department Universidad Antonio Narino Cauca Popayan
dc.description.affiliationDiagnostics Sector Immunology Laboratory Pasteur Institute of São Paulo
dc.description.affiliationCentro de Controle de Zoonoses Coordenadoria de vigilância em saúde
dc.description.affiliationUnespSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp)
dc.identifierhttp://dx.doi.org/10.3389/fvets.2021.681423
dc.identifier.citationFrontiers in Veterinary Science, v. 8.
dc.identifier.doi10.3389/fvets.2021.681423
dc.identifier.issn2297-1769
dc.identifier.scopus2-s2.0-85117140162
dc.identifier.urihttp://hdl.handle.net/11449/231532
dc.language.isoeng
dc.relation.ispartofFrontiers in Veterinary Science
dc.sourceScopus
dc.subjectantibodies
dc.subjectrabies
dc.subjectRFFIT
dc.subjectserology
dc.subjectvampire bats
dc.subjectvirus neutralizing antibodies
dc.titleSerological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundusen
dc.typeArtigo

Arquivos

Coleções

Artigos - Microbiologia e Imunologia - IBB