Action mode of triazines and toxic effects on vertebrates

dc.contributor.authorSeveri-Aguiar, G. D.C.
dc.contributor.authorSilva-Zacarin, E. C.M.
dc.contributor.authorCampos-Pereira, F. D. [UNESP]
dc.contributor.authorAlves, A. A.
dc.contributor.institutionUNIARARAS
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:01:41Z
dc.date.available2022-04-28T19:01:41Z
dc.date.issued2013-01-01
dc.description.abstractTriazines are the family of herbicides that include atrazine, ametryn and simazine that are widely used in Brazil and can contaminate groundwater. Cattle can accumulate herbicides in their body through ingestion plants infested with these compounds and one of the ways, by which, human beings are exposed to atrazine is through cattle meat and milk consumption. The toxicity of these compounds can be explained mainly by their interaction with microsomal biotransformation processes. The herbicides per se or their metabolites or the secondary products of oxidative stress interact with biomolecules such proteins and DNA affecting a lot of cellular types. Cellular effects of chemicals might involve recruitment or de-repression of cell death mechanisms. Whether a cell survives or dies in the presence of a chemical insult is often determined by proliferative status, repair enzyme capacity, and the ability to induce proteins that either promote or inhibit the cell death process. In this chapter we will present an extensive bibliographical review about this herbicide class focusing its effects on vertebrates, looking for defense cellular mechanisms, at morphological and biochemical levels.en
dc.description.affiliationCentro Universitário Hermínio Ometto UNIARARAS
dc.description.affiliationLaboratório de Biologia Estrutural e Funcional (LABEF) Universidade Federal de São Carlos - UFSCAR, Rodovia João Leme dos Santos
dc.description.affiliationLaboratório de Mutagênese Ambiental (LMA) Universidade Estadual Paulista - UNESP
dc.description.affiliationUnespLaboratório de Mutagênese Ambiental (LMA) Universidade Estadual Paulista - UNESP
dc.format.extent133-149
dc.identifier.citationHandbook on Herbicides: Biological Activity, Classification and Health and Environmental Implications, p. 133-149.
dc.identifier.scopus2-s2.0-84945450650
dc.identifier.urihttp://hdl.handle.net/11449/220482
dc.language.isoeng
dc.relation.ispartofHandbook on Herbicides: Biological Activity, Classification and Health and Environmental Implications
dc.sourceScopus
dc.titleAction mode of triazines and toxic effects on vertebratesen
dc.typeCapítulo de livro

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