Central angiotensin II induces sodium bicarbonate intake in the rat

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Data

2008-07-01

Autores

David, Richard B. [UNESP]
Menani, José Vanderlei [UNESP]
De Luca, Laurival A. [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Academic Press Ltd Elsevier B.V. Ltd

Resumo

The aim of this work was to test mineral preference in hydrated rats that received a pulse intracerebroventricular (icv(p)) injection of ANG II at a dipsogenic dose (50 ng). The icv(p) ANG II induced a four-fold higher ingestion of 0.15 M NaHCO(3) than of other mineral solutions at palatable concentrations (0.15 M NaCl, 0.05 mM CaCl(2) and 0.01 M KCl) in a five-bottle test with water available in a fifth bottle; water intake was not consistently high in this test. Contrary to what is predicted by the mineralocorticoid/angiotensin II synergy hypothesis, the 0.15 M NaCl intake in the five-bottle test was not enhanced by icvp ANG H preceded by deoxycorticosterone (DOCA) treatment (2.5 mg/day for 3 days); neither was the NaHCO(3) intake. This result contrasted with the vigorous ingestion of both isotonic sodium solutions, but mostly of NaCl, rather than of other fluids, by sodium-depleted (furosemide 10 mg sc + 24 h removal ambient sodium) rats in a sodium appetite test. The results suggest that mineralocorticoid combined to icv(p) ANG II does not simulate the sodium preference shown during sodium appetite. The results also show that a dipsogenic dose of central ANG II induces a reliable ingestion of isotonic sodium bicarbonate in the rat. (C) 2007 Elsevier Ltd. All rights reserved.

Descrição

Palavras-chave

sodium appetite, mineral preference, NaHCO(3) intake, angiotensin II, mineralocorticoid, sodium depletion, synergy

Como citar

Appetite. London: Academic Press Ltd- Elsevier B.V. Ltd, v. 51, n. 1, p. 82-89, 2008.