Inhibition of bovine brain acetylcholinesterase by aluminum.

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dc.contributor.authorMoraes, M. S. [UNESP]
dc.contributor.authorLeite, S. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T18:54:05Z
dc.date.available2022-04-28T18:54:05Z
dc.date.issued1994-01-01
dc.description.abstractWe report the in vitro inhibitory effect of very low concentrations of aluminum salts (IC50 = 4.1 x 10(-12 M) on bovine brain acetylcholinesterase (AChE). The enzymatic assays were performed using acetylcholine bromide in a buffered pH 7.4 solution at 37 degrees C. The relevant enzyme interacting species is the Al3+ ion, whose concentrations were fixed at pM levels by a citrate metal ion buffer system. The IC50 demonstrates that Al3+ is a potent inhibitor of AChE.en
dc.description.affiliationInstituto de Química Universidade Estadual Paulista SP.
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista SP.
dc.format.extent2635-2638
dc.identifier.citationBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 27, n. 11, p. 2635-2638, 1994.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0028543588
dc.identifier.urihttp://hdl.handle.net/11449/219172
dc.language.isoeng
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]
dc.sourceScopus
dc.titleInhibition of bovine brain acetylcholinesterase by aluminum.en
dc.typeArtigo

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