Modulatory effect of Byrsonima basiloba extracts on the mutagenicity of certain direct and indirect-acting mutagens in Salmonella typhimurium assays
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2008-03-01
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Byrsonima basiloba A. Juss. species is a native arboreal type from the Brazilian cerrado (tropical American savanna), and the local population uses it to treat diseases, such as diarrhea and gastric ulcer. It belongs to the Malpighiaceae family, and it is commonly known as murici. Considering the popular use of B. basiloba derivatives and the lack of pharmacological potential studies regarding this vegetal species, the mutagenic and antimutagenic effect of methanol (MeOH) and chloroform extracts were evaluated by the Ames test, using strains TA97a, TA98, TA100, and TA102 of Salmonella typhimurium. No mutagenic activity was observed in any of the extracts. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine, sodium azide, mitomycin C, aflatoxin B1, benzo[a]pyrene, and hydrogen peroxide. Both the extracts evaluated showed antimutagenic activity, but the highest value of inhibition level (89%) was obtained with the MeOH extract and strain TA100 in the presence of aflatoxin B1. Phytochemical analysis of the extracts revealed the presence of n-alkanes, lupeol, ursolic and oleanolic acid, (+)-catechin, quercetin-3-O-α-L-arabinopyranoside, gallic acid, methyl gallate, amentoflavone, quercetin, quercetin-3-O-(2″-O-galloyl)-β-D- galactopyranoside, and quercetin-3-O-(2″-O-galloyl)-α-L- arabinopyranoside. © 2008 Mary Ann Liebert, Inc.
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Ames test, Antimutagenic, Byrsonima, Mutagenic, 4 nitro o phenylenediamine, aflatoxin B1, alkane, amentoflavone, benzo[a]pyrene, Byrsonima basiloba extract, catechin, chloroform, gallic acid, gallic acid methyl ester, hydrogen peroxide, lupeol, methanol, mitomycin C, mutagenic agent, oleanolic acid, plant extract, quercetin, quercetin 3 o (2'' o galloyl) alpha dextro galactopyranoside, quercetin 3 o (2'' o galloyl) beta dextro galactopyranoside, quercetin 3 o alpha levo arabinopyranoside, quercetin 3 o beta galactopyranoside, quercetin derivative, sodium azide, unclassified drug, ursolic acid, arboreal species, bacterial strain, Byrsonima basiloba, controlled study, drug effect, drug inhibition, mutagen testing, mutagenicity, nonhuman, phytochemistry, priority journal, Salmonella typhimurium, Antimutagenic Agents, Chloroform, Flavonoids, Malpighiaceae, Methanol, Mutagenicity Tests, Mutagens, Plant Extracts, Plant Leaves
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Inglês
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Journal of Medicinal Food, v. 11, n. 1, p. 111-119, 2008.