Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease

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dc.contributor.authorFonseca-Santos, Bruno [UNESP]
dc.contributor.authorCazarin, Camila André
dc.contributor.authorda Silva, Patrícia Bento
dc.contributor.authordos Santos, Kaio Pini [UNESP]
dc.contributor.authorda Rocha, Márcia Cristina Oliveira
dc.contributor.authorBáo, Sônia Nair
dc.contributor.authorDe-Souza, Márcia Maria
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionPostgraduate in Pharmaceutical Sciences
dc.contributor.institutionUniversity of Brasilia (UnB)
dc.date.accessioned2023-07-29T16:15:12Z
dc.date.available2023-07-29T16:15:12Z
dc.date.issued2023-07-01
dc.description.abstractAlzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing oleic acid, CETETH-20 and water. Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and transmission electron microscopy (TEM) confirm the initial liquid formulation (F) presented as microemulsion (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation via inhibition of interleukin.en
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences, São Paulo
dc.description.affiliationFederal University of Bahia (UFBA) Health Sciences Institute Department of Biotechnology, Bahia
dc.description.affiliationUniversity of Vale do Itajaí (UNIVALI) Postgraduate in Pharmaceutical Sciences, Santa Catarina
dc.description.affiliationDepartment of Genetics and Morphology Institute of Biological Sciences University of Brasilia (UnB), Federal District
dc.description.affiliationMicroscopy and Microanalysis Laboratory Department of Cell Biology Institute of Biological Sciences University of Brasilia (UnB), Federal District
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 15/05394-2
dc.description.sponsorshipIdFAPESP: 2014/50928-2
dc.description.sponsorshipIdCNPq: 465687/2014-8
dc.identifierhttp://dx.doi.org/10.1016/j.nano.2023.102689
dc.identifier.citationNanomedicine: Nanotechnology, Biology, and Medicine, v. 51.
dc.identifier.doi10.1016/j.nano.2023.102689
dc.identifier.issn1549-9642
dc.identifier.issn1549-9634
dc.identifier.scopus2-s2.0-85160454264
dc.identifier.urihttp://hdl.handle.net/11449/250004
dc.language.isoeng
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicine
dc.sourceScopus
dc.subjectBrain
dc.subjectColloids
dc.subjectMicroemulsion
dc.subjectNeurological disease
dc.subjectPolyoxyethylene (20) oleyl ether
dc.titleIntranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's diseaseen
dc.typeArtigo
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas