Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

dc.contributor.authorMiki Stein, Angelica [UNESP]
dc.contributor.authorMunive, Victor
dc.contributor.authorFernandez, Ana M.
dc.contributor.authorNunez, Angel
dc.contributor.authorTorres Aleman, Ignacio
dc.contributor.institutionCajal Inst Neurobiol
dc.contributor.institutionCiberned
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Autonoma Madrid
dc.date.accessioned2018-11-26T15:44:17Z
dc.date.available2018-11-26T15:44:17Z
dc.date.issued2017-05-22
dc.description.abstractAge is the main risk factor for Alzheimer A s disease (AD). With an increasingly aging population, development of affordable screening techniques to determine cognitive status will help identify population-at-risk for further follow-up. Because physical exercise is known to modulate cognitive performance, we used it as a functional test of cognitive health. Mice were submitted to treadmill running at moderate speed for 30 min, and their brain activity was monitored before and after exercise using electrocorticogram (ECG) recordings. After exercise, normal, but not APP/PS1 mice, a well established AD model, showed significantly increased ECG theta rhythm. At the same time normal, but not AD mice, showed significantly enhanced performance in a spatial memory test after exercise. Therefore, we postulate that a running bout coupled to pre-and post-exercise brain activity recordings will help identify individuals with cognitive alterations, by determining the presence or absence of exercise-specific changes in brain activity. Work in humans using a bout of moderate exercise plus electroencephalography, a clinically affordable procedure, is warranted.en
dc.description.affiliationCajal Inst Neurobiol, Madrid, Spain
dc.description.affiliationCiberned, Madrid, Spain
dc.description.affiliationUniv Estadual Paulista, Sao Paulo, Brazil
dc.description.affiliationUniv Autonoma Madrid, Sch Med, Madrid, Spain
dc.description.affiliationUnespUniv Estadual Paulista, Sao Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Estadual Paulista (Brazil)
dc.description.sponsorshipFPI fellowship
dc.description.sponsorshipCiberned
dc.description.sponsorshipIdCAPES: PDSE 99999.010743/2014-06
dc.description.sponsorshipIdFAPESP: 2013/19729-0
dc.description.sponsorshipId: SAF2013-40710-R/SAF2016-76462 AEI/FEDER
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0178247
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 12, n. 5, 11 p., 2017.
dc.identifier.doi10.1371/journal.pone.0178247
dc.identifier.fileWOS000402058400072.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11449/159558
dc.identifier.wosWOS:000402058400072
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleAcute exercise does not modify brain activity and memory performance in APP/PS1 miceen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.orcid0000-0001-8107-7947[5]

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