Prevalence of gingival hyperplasia induced by anticonvulsants: A systematic review

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dc.contributor.authorCláudio, Marina Módolo [UNESP]
dc.contributor.authorRodrigues, João Victor Soares [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia
dc.contributor.authorTheodoro, Leticia Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLatin American Institute of Dental Research and Education (ILAPEO)
dc.date.accessioned2021-06-25T10:49:25Z
dc.date.available2021-06-25T10:49:25Z
dc.date.issued2021-01-01
dc.description.abstractObjective: Gingival hyperplasia (GH) is one of the side effects of anticonvulsant drugs. The aim of this study was to verify the prevalence of GH associated with the use of anticonvulsant, through a systematic review. Material and Methods: Systematic search was done at databases Pubmed and Embase between January 1984 and March of 2020 for identification of articles addressing the prevalence of GH associated with the use of anticonvulsant drugs. The methodological index for non-randomized studies (MINORS) was independently assessed for quality in the selected papers. Results: The search identified 4.471 references. Nine articles were selected and evaluated 632 participants. All of the studies included in the systematic review showed a low risk of bias. The anticonvulsants used by patients were carbamazepine, ethosuximide, phenytoin, primidone, phenobarbital, sodium valproate. The studies showed a correlation between different types of anticonvulsants and GH prevalence, with a range from 0% to 73%. Among the anticonvulsants used, phenytoin showed the greatest incidence of GH, varying between 15.61% and 73% in patients. Conclusion: In the analysis of the results obtained in the literature, it is possible to notice that the great majority of studies presented incidence of GH associated with anticonvulsant use. However, further studies are necessary to understand the anticonvulsant action mechanism inducing GH, as well as the prevention forms, given that GH is a significant side effect.en
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Diagnostic and Surgery Division of Periodontology
dc.description.affiliationLatin American Institute of Dental Research and Education (ILAPEO)
dc.description.affiliationDental Assistance Center for Disabled Persons (CAOE) Department of Diagnostic and Surgery Division of Periodontology São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Diagnostic and Surgery Division of Periodontology
dc.description.affiliationUnespDental Assistance Center for Disabled Persons (CAOE) Department of Diagnostic and Surgery Division of Periodontology São Paulo State University (UNESP) School of Dentistry
dc.format.extent1-9
dc.identifierhttp://dx.doi.org/10.14295/bds.2021.v24i1.2112
dc.identifier.citationBrazilian Dental Science, v. 24, n. 1, p. 1-9, 2021.
dc.identifier.doi10.14295/bds.2021.v24i1.2112
dc.identifier.issn2178-6011
dc.identifier.scopus2-s2.0-85099274190
dc.identifier.urihttp://hdl.handle.net/11449/207126
dc.language.isoeng
dc.relation.ispartofBrazilian Dental Science
dc.sourceScopus
dc.subjectAnticonvulsants
dc.subjectGingival hyperplasia
dc.subjectPrevalence
dc.titlePrevalence of gingival hyperplasia induced by anticonvulsants: A systematic reviewen
dc.titlePrevalência da hiperplasia gengival induzida pelo uso de anticonvulsivantes: Revisão sistemáticapt
dc.typeResenha

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Araçatuba - CAOE - Centro de Assistência Odontológica a Excepcionais