Natural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth.

dc.contributor.authorHiruma-Lima, C. A.
dc.contributor.authorToma, W.
dc.contributor.authorGracioso, J. D.
dc.contributor.authorde Almeida, ABA
dc.contributor.authorBatista, L. M.
dc.contributor.authorMagri, L.
dc.contributor.authorde Paula, ACB
dc.contributor.authorSoares, F. R.
dc.contributor.authorNunes, D. S.
dc.contributor.authorBrito, ARMS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Estadual Ponta Grossa
dc.date.accessioned2014-05-20T15:28:06Z
dc.date.available2014-05-20T15:28:06Z
dc.date.issued2002-04-01
dc.description.abstractThe nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.) at the dose of 100 mg/kg, crotonin, as well as DHC, significantly reduced (p<0.05) gastric injury induced by stress (72, 67%), indomethacin/bethanechol (78, 29%) and pylorus ligature (35, 30%). In the HCl/ethanol-induced gastric ulcer model, at oral doses of 100 and 250 mg/kg, crotonin significantly prevented (p<0.05) the formation of gastric lesions by 51 and 56%, respectively, when compared to the control group. Gastric injury was also of significantly less magnitude in the DHC treatment group (p<0.05). In the pylorus-ligature model, crotonin (p.o.), like cimetidine, increased the volume of gastric juice when compared to the control group (p<0.05). No significant modifications where found in gastric parameters such as pH or total acid content after oral crotonin treatment. However, systemic alterations were observed when crotonin (100 mg/kg) was previously administered intraduodenally to mice. We observed significant changes (p<0.001) in gastric-juice parameters such as an increase in volume and a decrease in gastric acidity. Those pre-treated with crotonin as well as with DHC did not increase free mucus production (p>0.05). The results suggest that crotonin presents a significant anti-ulcer effect when assessed in these ulcer-induced models. As with DHC, the antiulcerogenic effects of crotonin are probably related to anti-secretory or/and gastroprotective properties of this substance. In light of results obtained with DHC and natural trans-crotonin in the present study, we concluded that the A-ring of both diterpenes is not directly involved in the antiulcerogenic activity.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, São Paulo, Brazil
dc.description.affiliationUniv Estadual Ponta Grossa, Dept Quim, Ponta Grossa, Parana, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618000 São Paulo, Brazil
dc.format.extent452-456
dc.identifierhttp://dx.doi.org/10.1248/bpb.25.452
dc.identifier.citationBiological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 25, n. 4, p. 452-456, 2002.
dc.identifier.doi10.1248/bpb.25.452
dc.identifier.fileWOS000174690200010.pdf
dc.identifier.issn0918-6158
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.urihttp://hdl.handle.net/11449/37988
dc.identifier.wosWOS:000174690200010
dc.language.isoeng
dc.publisherPharmaceutical Soc Japan
dc.relation.ispartofBiological & Pharmaceutical Bulletin
dc.relation.ispartofjcr1.694
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcrotonin DHCpt
dc.subjectgastroprotective activitypt
dc.subjectCroton cajucarapt
dc.subjectditerpenept
dc.subjectEuphorbiaceaept
dc.titleNatural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth.en
dc.typeArtigo
dcterms.licensehttp://bpb.pharm.or.jp/document/transfer.pdf
dcterms.rightsHolderPharmaceutical Soc Japan
unesp.author.lattes3814504901386844[1]
unesp.author.orcid0000-0002-8645-3777[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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