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Gut dysbiosis in mice genetically selected for low antibody production

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dc.contributor.authorDa Silva Santos, Ana Carolina [UNESP]
dc.contributor.authorJensen, José Ricardo
dc.contributor.authorDe Oliveira, Silvio Luis [UNESP]
dc.contributor.authorRodrigues, Josias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionButantan Institute
dc.date.accessioned2018-12-11T17:13:51Z
dc.date.available2018-12-11T17:13:51Z
dc.date.issued2017-08-07
dc.description.abstractBackground: Dysbiosis is linked to the cause of several human diseases, many of which having an immunity related component. This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fecal 16SV6-V8 rDNA PCR amplicons resolved by temperature gradient gel electrophoresis (TGGE) of five each of low (LIII) and high (HIII) antibody producing mice. 16SV6 rDNA amplicons of 2 mice from each line were sequenced. Results: LIII mice were grouped in a single TGGE cluster, displayed a low α-diversity, and were distinguished by low Firmicutes/Bacteroidetes ratio. Conclusion: The results suggest that genetically driven low antibody production in mice is associated with gut dysbiosis.en
dc.description.affiliationDepartment of Microbiology and Immunology Institute of Biosciences State University of São Paulo (UNESP) Campus de Rubião Junior
dc.description.affiliationLaboratory of Immunogenetics Butantan Institute, Av. Dr. Vital Brazil 1500
dc.description.affiliationUnespDepartment of Microbiology and Immunology Institute of Biosciences State University of São Paulo (UNESP) Campus de Rubião Junior
dc.identifierhttp://dx.doi.org/10.1186/s13099-017-0193-x
dc.identifier.citationGut Pathogens, v. 9, n. 1, 2017.
dc.identifier.doi10.1186/s13099-017-0193-x
dc.identifier.file2-s2.0-85026904613.pdf
dc.identifier.issn1757-4749
dc.identifier.scopus2-s2.0-85026904613
dc.identifier.urihttp://hdl.handle.net/11449/175015
dc.language.isoeng
dc.relation.ispartofGut Pathogens
dc.relation.ispartofsjr1,066
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntibody
dc.subjectBacteroidetes
dc.subjectFirmicutes
dc.subjectMicrobiome
dc.subjectPrevotellaceae
dc.subjectRuminococcaceae
dc.titleGut dysbiosis in mice genetically selected for low antibody productionen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0001-8480-672X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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