Three-dimensional culture models: emerging platforms for screening the antitumoral efficacy of nanomedicines

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dc.contributor.authorTofani, Larissa Bueno
dc.contributor.authorLuiz, Marcela Tavares [UNESP]
dc.contributor.authorPaes Dutra, Jessyca Aparecida [UNESP]
dc.contributor.authorAbriata, Juliana Palma
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:15:13Z
dc.date.available2023-07-29T16:15:13Z
dc.date.issued2023-03-01
dc.description.abstractNanomedicines have been investigated for delivering drugs to tumors due to their ability to accumulate in the tumor tissues. 2D in vitro cell culture has been used to investigate the antitumoral potential of nanomedicines. However, a 2D model cannot adequately mimic the in vivo tissue conditions because of the lack of cell-cell interaction, a gradient of nutrients and the expression of genes. To overcome this limitation, 3D cell culture models have emerged as promising platforms that better replicate the complexity of native tumors. For this purpose, different techniques can be used to produce 3D models, including scaffold-free, scaffold-based and microfluidic-based models. This review addresses the principles, advantages and limitations of these culture methods for evaluating the antitumoral efficacy of nanomedicines.en
dc.description.affiliationSchool of Pharmaceutical Science of Ribeirao Preto University of Sao Paulo (USP)
dc.description.affiliationSchool of Pharmaceutical Science of Sao Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Science of Sao Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCAPES: 001
dc.format.extent633-647
dc.identifierhttp://dx.doi.org/10.2217/nnm-2022-0205
dc.identifier.citationNanomedicine (London, England), v. 18, n. 7, p. 633-647, 2023.
dc.identifier.doi10.2217/nnm-2022-0205
dc.identifier.issn1748-6963
dc.identifier.scopus2-s2.0-85160457407
dc.identifier.urihttp://hdl.handle.net/11449/250005
dc.language.isoeng
dc.relation.ispartofNanomedicine (London, England)
dc.sourceScopus
dc.subjectcancer therapy
dc.subjectdrug-delivery systems
dc.subjectmulticellular spheroids
dc.subjectscaffold-based model and microfluids devices
dc.subjectscaffold-free model
dc.titleThree-dimensional culture models: emerging platforms for screening the antitumoral efficacy of nanomedicinesen
dc.typeResenha
unesp.author.orcid0000-0003-4869-3697[1]
unesp.author.orcid0000-0002-6090-6352[2]
unesp.author.orcid0000-0001-8802-0054[3]
unesp.author.orcid0000-0002-6345-5753[4]
unesp.author.orcid0000-0002-6698-0545[5]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas