Gallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assays

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dc.contributor.authorMonteiro e Silva, Silas Arandas
dc.contributor.authorCalixto, Giovana Maria Fioramonti [UNESP]
dc.contributor.authorCajado, Juliana
dc.contributor.authorde Carvalho, Patrícia Caballieri Antunes
dc.contributor.authorRodero, Camila Fernanda [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorLeonardi, Gislaine Ricci
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-12-11T17:33:52Z
dc.date.available2018-12-11T17:33:52Z
dc.date.issued2017-08-24
dc.description.abstractOxidative stress, which is a result of overproduction and accumulation of free radicals, is the main cause of several skin degenerative diseases, such as aging. Polyphenols, such as gallic acid, are an important class of naturally occurring antioxidants. They have emerged as strong antioxidants that can be used as active cosmetics. The purpose of this study was to develop a gallic acid-loaded cosmetic gel formulation and characterize it using rheological, mechanical, and bioadhesive tests. Its antioxidant effect in the stratum corneum was evaluated by a non-invasive method. According to the characterization tests, the formulation exhibited skin adhesiveness and pseudoplastic behavior without thixotropy, rendering it suitable for use as a cosmetic formulation. Furthermore, the non-invasive method indicated the antioxidant effect in the stratum corneum, with the global lipid peroxide reduction being 33.97 ± 11.66%. Thus, we were able to develop a promising gallic acid-loaded gel formulation that could reduce lipid peroxides and thus combat skin oxidative stress.en
dc.description.affiliationMedicine Department Federal University of Sao Paulo (UNIFESP)
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Food Science São Paulo University (USP)
dc.description.affiliationInstitute of Environmental Chemistry and Pharmaceutical Sciences Federal University of Sao Paulo (UNIFESP)
dc.description.affiliationFaculty of Pharmaceuticals Sciences University of Campinas (UNICAMP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/polym9090391
dc.identifier.citationPolymers, v. 9, n. 9, 2017.
dc.identifier.doi10.3390/polym9090391
dc.identifier.file2-s2.0-85028406270.pdf
dc.identifier.issn2073-4360
dc.identifier.scopus2-s2.0-85028406270
dc.identifier.urihttp://hdl.handle.net/11449/179129
dc.language.isoeng
dc.relation.ispartofPolymers
dc.relation.ispartofsjr0,852
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidants
dc.subjectGallic acid
dc.subjectPolymers
dc.subjectSkin administration
dc.titleGallic acid-loaded gel formulation combats skin oxidative stress: development, characterization and ex vivo biological assaysen
dc.typeArtigo
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas