Biosynthesis of silver nanoparticles of Tribulus terrestris food supplement and evaluated antioxidant activity and collagenase, elastase and tyrosinase enzyme inhibition: In vitro and in silico approaches

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dc.contributor.authorFigueiredo, Célia Cristina Malaguti [UNESP]
dc.contributor.authorda Costa Gomes, Amanda [UNESP]
dc.contributor.authorZibordi, Laura Camargo [UNESP]
dc.contributor.authorGranero, Filipe Oliveira [UNESP]
dc.contributor.authorXimenes, Valdecir Farias [UNESP]
dc.contributor.authorPavan, Nathalia Mariana [UNESP]
dc.contributor.authorSilva, Luciana Pereira
dc.contributor.authorSonvesso, Cibely da Silva Martin [UNESP]
dc.contributor.authorJob, Aldo Eloizo [UNESP]
dc.contributor.authorNicolau-Junior, Nilson
dc.contributor.authorSilva, Regildo Márcio Gonçalves da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFundação Educacional do Município de Assis (FEMA)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2023-07-29T16:05:07Z
dc.date.available2023-07-29T16:05:07Z
dc.date.issued2023-03-01
dc.description.abstractFood supplements from plants are source of many antioxidant substances. Tribulus terrestris food supplement (TtFS) is highlighted as one of these supplements that has presented potential to prevent damages and diseases caused by oxidative stress. In addition, new formulations that enhance the benefits of food supplement have been developed and metallic nanoparticles, the so-called green synthesis, has been of great interest. UV–visible spectroscopy, energy dispersive spectroscopy (EDS), Zeta potential (ZP), scanning transmission electron microscopy (STEM), scanning electron microscope (SEM) were used to characterize the synthesized silver nanoparticles (AgNPs). Antioxidant activity was determined by DPPH radical scavenging, ferric ion reducing power (FRAP); ABTS radical scavenging, and oxygen radical absorption capacity (ORAC-FL). Molecular docking analyses were performed to evaluate molecular interactions. Antioxidant evaluation of TtFS demonstrated 83.6% antioxidant activity (DPPH), 714.82 μM Trolox Equivalent (TE)/g sample (FRAP), 91.24 μM TE/g sample (ABTS), and antioxidant activity in ORAC assay. It presented inhibition activity on collagenase (75.33%), elastase (54.04%) and tyrosinase (59.07%). In addition, in silico assays showed an interaction between T. terrestris steroidal saponins and DNA, and the highest DNA binding affinity was observed with protodioscin. Steroidal saponins also presented interaction with all enzymes evaluated. The characterization of AgNPs demonstrated that they were formed as a spherical shape. These AgNPs showed greater protective properties against oxidative stress (85.41% antioxidant activity (DPPH) and 957.55 μM TE/g sample (FRAP)). The results represent an important indicator for the development and discovery of new nanoestructured pharmaceutical and cosmetic formulation using plants and natural products.en
dc.description.affiliationSão Paulo State University (UNESP) Institute of Chemistry, São Paulo
dc.description.affiliationSão Paulo State University (UNESP) Departament of Chemistry Faculty of Science, São Paulo
dc.description.affiliationFundação Educacional do Município de Assis (FEMA), São Paulo
dc.description.affiliationSão Paulo State University (UNESP) Department of Physics, São Paulo
dc.description.affiliationLaboratory of Molecular Modeling Institute of Biotechnology Federal University of Uberlândia, Minas Gerais
dc.description.affiliationSão Paulo State University (UNESP) School of Sciences Humanities and Languages Department of Biotechnology Laboratory of Herbal Medicine and Natural Products, São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Chemistry, São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) Departament of Chemistry Faculty of Science, São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Physics, São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Sciences Humanities and Languages Department of Biotechnology Laboratory of Herbal Medicine and Natural Products, São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2015/17893–3
dc.format.extent150-161
dc.identifierhttp://dx.doi.org/10.1016/j.fbp.2023.01.010
dc.identifier.citationFood and Bioproducts Processing, v. 138, p. 150-161.
dc.identifier.doi10.1016/j.fbp.2023.01.010
dc.identifier.issn0960-3085
dc.identifier.scopus2-s2.0-85147607069
dc.identifier.urihttp://hdl.handle.net/11449/249638
dc.language.isoeng
dc.relation.ispartofFood and Bioproducts Processing
dc.sourceScopus
dc.subjectFood supplements
dc.subjectFunctional food
dc.subjectMolecular docking
dc.subjectOxidative stress
dc.subjectSteroidal saponins
dc.titleBiosynthesis of silver nanoparticles of Tribulus terrestris food supplement and evaluated antioxidant activity and collagenase, elastase and tyrosinase enzyme inhibition: In vitro and in silico approachesen
dc.typeArtigo
unesp.departmentQuímica - FCpt
unesp.departmentFísica, Química e Biologia - FCTpt

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Bauru - FC - Faculdade de Ciências
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