Accuracy of radiographic pixel linear analysis in detecting bone loss in periodontal disease: Study in diabetic rats

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dc.contributor.authorBueno, Carlos Roberto Emerenciano [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.authorDuarte, Marco Antônio Hungaro
dc.contributor.authorOrdinola-Zapata, Ronald
dc.contributor.authorAzuma, Mariane Maffei [UNESP]
dc.contributor.authorGuimarães, Gustav
dc.contributor.authorPinheiro, Tiago Novaes
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSchool of Dentistry
dc.contributor.institutionUniversity of Michigan
dc.contributor.institutionDental School of Amazonas State University
dc.date.accessioned2022-04-29T08:31:20Z
dc.date.available2022-04-29T08:31:20Z
dc.date.issued2021-01-01
dc.description.abstractIntroduction: Periodontitis, a complex infectious disease that may lead to irreversible loss of periodontium, is considered a predisposing agent for developing insulin resistance due to the release of inflammatory mediators, showing a bilateral relationship with diabetes mellitus. The investigation of periodontal disease requires a clinical approach and complete intraoral radiographs, even with increasing concerns about radiation exposure. Thus, this study assesses pixel linear analysis accuracy using digital radiography via Digora® in detecting alveolar bone destruction in diabetic rats with periodontal disease. Methodology: 40 rats were divided into groups (n = 10): control (C), rats with periodontal disease (PD), experimental diabetic rats (ED), experimental diabetic rats with periodontal disease (ED-PD). Diabetes was induced by streptozotocin and periodontal disease by periodontal ligature. After 30 days, maxillae bone destruction was obtained by linear analysis of vertical bone loss using digital radiography and then assessed by micro-CT and histology. Data were analyzed by ANOVA and Tukey's test (p < 0.05). Results: Radiographic, micro-CT and histological analysis presented accurate and similar results. PD and ED-PD groups showed higher bone destruction than C and ED groups (p < 0.05). Moreover, the ED-PD group had higher bone loss than the PD group (p < 0.05). Conclusion: The pixel linear analysis via digital radiography was an accurate, low-cost alternative in detecting alveolar bone loss in this rat model. Micro-CT and histological analysis may also be used to obtain linear measures to assess and compare periodontal bone destruction in diabetic rats.en
dc.description.affiliationDepartment of Preventive and Restorative Dentistry Endodontic Section School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationDepartment of Basic Science School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationDepartment of Dentistry Endodontics and Dental Materials School of Dentistry University of São Paulo – USP
dc.description.affiliationDivision of Endodontics University of Minnesota School of Dentistry
dc.description.affiliationDepartment of Cariology Restorative Sciences and Endodontics University of Michigan
dc.description.affiliationDepartment of Periodontics University Center São Lucas School of Dentistry
dc.description.affiliationDepartment of Oral Pathology and Oral Medicine Dental School of Amazonas State University
dc.description.affiliationDental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationDepartment of Endodontics State University of Northern Paraná (UENP) School of Dentistry
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry Endodontic Section School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationUnespDepartment of Basic Science School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationUnespDental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (Unesp) School of Dentistry
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1016/j.sdentj.2021.07.004
dc.identifier.citationSaudi Dental Journal.
dc.identifier.doi10.1016/j.sdentj.2021.07.004
dc.identifier.issn1013-9052
dc.identifier.scopus2-s2.0-85111510562
dc.identifier.urihttp://hdl.handle.net/11449/229230
dc.language.isoeng
dc.relation.ispartofSaudi Dental Journal
dc.sourceScopus
dc.subjectEmission-computed tomography
dc.subjectExperimental diabetes mellitus
dc.subjectHistology
dc.subjectPeriodontal disease
dc.subjectRadiography
dc.titleAccuracy of radiographic pixel linear analysis in detecting bone loss in periodontal disease: Study in diabetic ratsen
dc.typeArtigo

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Araçatuba - CAOE - Centro de Assistência Odontológica a Excepcionais