The Activity of Calcium Glycerophosphate and Fluoride against Cariogenic Biofilms of Streptococcus mutans and Candida albicans Formed In Vitro

Página do item simplificado
dc.contributor.authorCavazana, Thamires Priscila [UNESP]
dc.contributor.authorHosida, Thayse Yumi [UNESP]
dc.contributor.authorSampaio, Caio [UNESP]
dc.contributor.authorde Morais, Leonardo Antônio [UNESP]
dc.contributor.authorMonteiro, Douglas Roberto [UNESP]
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorDelbem, Alberto Carlos Botazzo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.date.accessioned2023-07-29T16:06:37Z
dc.date.available2023-07-29T16:06:37Z
dc.date.issued2023-02-01
dc.description.abstractThis study evaluated the effects of calcium glycerophosphate (CaGP), with or without fluoride (F), on dual-species biofilms of Streptococcus mutans and Candida albicans. The biofilms were treated three times with 0.125, 0.25, and 0.5% CaGP solutions, with or without 500 ppm F (NaF). Additionally, 500 and 1100 ppm F-solutions and artificial saliva served as controls. After the final treatment, the microbial viability and biofilm structure, metabolic activity, total biomass production, and the composition of the extracellular matrix composition were analyzed. Regardless of the presence of F, 0.25 and 0.5% CaGP promoted a higher biomass production and metabolic activity increase than the controls (p < 0.05). F-free CaGP solutions reduced bacterial cell population significantly more than the 500 ppm F group or the negative control (p < 0.05). All the groups reduced the proteins, and 0.5% CaGP combined with F led to the highest reduction in the carbohydrate and nucleic acids content of the extracellular matrix (p < 0.05). It can be concluded that CaGP alone affected the number of bacterial cells and, when combined with F, reduced its production of biomass, metabolic activity, and the expression of the extracellular matrix components.en
dc.description.affiliationDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.description.affiliationPostgraduate Program in Health Sciences University of Western São Paulo (UNOESTE), Rua José Bongiovani, 700—Cidade Universitária, SP
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, SP
dc.identifierhttp://dx.doi.org/10.3390/antibiotics12020422
dc.identifier.citationAntibiotics, v. 12, n. 2, 2023.
dc.identifier.doi10.3390/antibiotics12020422
dc.identifier.issn2079-6382
dc.identifier.scopus2-s2.0-85148888062
dc.identifier.urihttp://hdl.handle.net/11449/249693
dc.language.isoeng
dc.relation.ispartofAntibiotics
dc.sourceScopus
dc.subjectbiofilms
dc.subjectcalcium
dc.subjectdental caries
dc.subjectfluorides
dc.subjectphosphates
dc.titleThe Activity of Calcium Glycerophosphate and Fluoride against Cariogenic Biofilms of Streptococcus mutans and Candida albicans Formed In Vitroen
dc.typeArtigo
unesp.author.orcid0000-0001-5229-5259[5]
unesp.author.orcid0000-0002-1550-3933[6]
unesp.author.orcid0000-0002-8159-4853[7]

Arquivos

Coleções

Artigos - Odontologia Infantil e Social - FOA