Ionic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: a review

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dc.contributor.authorVeríssimo, Nathalia Vieira Porphirio [UNESP]
dc.contributor.authorMussagy, Cassamo Usemane
dc.contributor.authorBento, Heitor Buzetti Simões [UNESP]
dc.contributor.authorPereira, Jorge Fernando Brandão
dc.contributor.authorSantos-Ebinuma, Valéria de Carvalho [UNESP]
dc.contributor.institutionUniversidade de São Paulo
dc.contributor.institutionPontificia Universidad Católica de Valparaíso
dc.contributor.institutionUniversidade de Coimbra
dc.date.accessioned2024-02-23T13:22:08Z
dc.date.available2024-02-23T13:22:08Z
dc.date.issued2024-01-08
dc.description.abstractBiopharmaceuticals have allowed the control of previously untreatable diseases. However, their low solubility and stability still hinder their application, transport, and storage. Hence, researchers have applied different compounds to preserve and enhance the delivery of biopharmaceuticals, such as ionic liquids (ILs) and deep eutectic solvents (DESs). Although the biopharmaceutical industry can employ various substances for enhancing formulations, their effect will change depending on the properties of the target biomolecule and environmental conditions. Hence, this review organized the current state-of-the-art on the application of ILs and DESs to stabilize biopharmaceuticals, considering the properties of the biomolecules, ILs, and DESs classes, concentration range, types of stability, and effect. We also provided a critical discussion regarding the potential utilization of ILs and DESs in pharmaceutical formulations, considering the restrictions in this field, as well as the advantages and drawbacks of these substances for medical applications. Overall, the most applied IL and DES classes for stabilizing biopharmaceuticals were cholinium-, imidazolium-, and ammonium-based, with cholinium ILs also employed to improve their delivery. Interestingly, dilute and concentrated ILs and DESs solutions presented similar results regarding the stabilization of biopharmaceuticals. With additional investigation, ILs and DESs have the potential to overcome current challenges in biopharmaceutical formulation.en
dc.description.versionPostprint
dc.identifier.citationVERÍSSIMO, N. V. P.; MUSSAGY, C. U.; BENTO, H. B. S.; PEREIRA, J. F. B.; SANTOS-EBINUMA, V. C. Ionic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: a review. Biotechnology Advances, v. 71, 108316, 2024. DOI: https://doi.org/10.1016/j.biotechadv.2024.108316.pt
dc.identifier.doihttps://doi.org/10.1016/j.biotechadv.2024.108316
dc.identifier.issn1873-1899
dc.identifier.issn0734-9750
dc.identifier.lattes4784418300101311
dc.identifier.lattes5103227458697229
dc.identifier.lattes9913041375494177
dc.identifier.orcid0000000199786864
dc.identifier.orcid0000000206293196
dc.identifier.orcid0000000266666695
dc.identifier.urihttps://hdl.handle.net/11449/253416
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofBiotechnology Advances
dc.rights.accessRightsAcesso restrito
dc.subjectproteinsen
dc.subjectnucleic aciden
dc.subjectneoteric solventsen
dc.subjectstability of biomoleculesen
dc.subjectpharmaceutical formulationsen
dc.subjectpreservativesen
dc.subjectbiopharmaceuticalsen
dc.subjectILsen
dc.subjectDESsen
dc.subjectprotein stabilityen
dc.titleIonic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: a reviewen
dc.title.alternativeLíquidos iônicos e solventes eutéticos profundos para a estabilização de produtos biofarmacêuticos: uma revisãopt
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara
unesp.departmentBioprocessos e Biotecnologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas