Physicochemical Characterization and Development of a Microemulsion System for Transdermal Use

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dc.contributor.authorSilva, Jose A.
dc.contributor.authorBedor, Danilo C. G.
dc.contributor.authorDamasceno, Bolivar P. G. L.
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.authorEgito, E. Socrates T.
dc.contributor.authorSantana, Davi P.
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionUniversidade Estadual da Paraiba
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:48Z
dc.date.available2014-05-20T13:24:48Z
dc.date.issued2010-01-01
dc.description.abstractA microemulsion (ME) carrier system containing diclofenac diethylamine (DDA) was developed and physicochemically characterized. In addition, a methodology for analytical determination of DDA by UV-Vis spectrophotometry was validated. The methodology used to produce the ME was simple and reliable, producing a stable ME system with a high DDA entrapment efficiency of 89.6 +/- 14.19%. The ME system presents a mean droplet size, conductivity, pH, refractive index and viscosity of around 50 nm, 300 mu S cm(-1), 7.0, 1.399, and 110 mPa, respectively. Furthermore, the analytical method developed to evaluate the DDA content was validated and used to quantify DDA in the ME formulations.en
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), CCS, DFAR, LASID, BR-59094450 Natal, RN, Brazil
dc.description.affiliationUniversidade Federal de Pernambuco (UFPE), Dept Ciencias Farmaceut, Programa Posgrad Ciencias Farmaceut, Recife, PE, Brazil
dc.description.affiliationUniv Estadual Paraiba, Dept Farm, Campina Grande, PB, Brazil
dc.description.affiliationUniv Estadual Paraiba, Ctr Ciencias Biol & Sociais & Aplicadas, Joao Pessoa, Barbados
dc.description.affiliationUniv Estadual Paulista, Dept Farmacos & Medicamentos, Programa Posgrad Ciencias Farmaceut, Araraquara, Barbados
dc.description.affiliationUnespUniv Estadual Paulista, Dept Farmacos & Medicamentos, Programa Posgrad Ciencias Farmaceut, Araraquara, Barbados
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipUEPB
dc.format.extent1-8
dc.identifierhttp://dx.doi.org/10.1080/01932690902735611
dc.identifier.citationJournal of Dispersion Science and Technology. Philadelphia: Taylor & Francis Inc, v. 31, n. 1, p. 1-8, 2010.
dc.identifier.doi10.1080/01932690902735611
dc.identifier.issn0193-2691
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/7794
dc.identifier.wosWOS:000275860200001
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Dispersion Science and Technology
dc.relation.ispartofjcr1.454
dc.relation.ispartofsjr0,375
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDiclofenac diethylamineen
dc.subjectmicroemulsionen
dc.subjectpseudo-ternary phase-diagramen
dc.subjectspectrophotometryen
dc.subjectstabilityen
dc.subjectvalidationen
dc.titlePhysicochemical Characterization and Development of a Microemulsion System for Transdermal Useen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes9114495952533044[4]
unesp.author.orcid0000-0002-2180-3991[5]
unesp.author.orcid0000-0002-0107-9940[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas