Dietary restriction and fibre supplementation: Oxidative stress and metabolic shifting for cardiac health

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dc.contributor.authorDiniz, Yeda S. [UNESP]
dc.contributor.authorCicogna, Antonio C. [UNESP]
dc.contributor.authorPadovani, Carlos R. [UNESP]
dc.contributor.authorSilva, Maeli D. P. [UNESP]
dc.contributor.authorFaine, Luciane A. [UNESP]
dc.contributor.authorGalhardi, Cristiano M.
dc.contributor.authorRodrigues, Hosana G.
dc.contributor.authorNovelli, Ethel L. B.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:55Z
dc.date.available2014-05-27T11:20:55Z
dc.date.issued2003-11-01
dc.description.abstractDietary modification ought to be the first line of strategy in prevention of the development of cardiac disease. The purpose of this study was to investigate whether dietary restriction, dietary-fibre-enriched diet, and their interactions might affect antioxidant capacity and oxidative stress in cardiac tissue. Male Wistar rats (180-200 g; n = 10) were divided into four groups: control ad libitum diet (C), 50% restricted diet (DR), fed with fibre-enriched diet (F), and 50% restricted fibre-enriched diet (DR-F). After 35 days of the treatments, F, DR, and DR-F rats showed low cholesterol, LDL-cholesterol, and triacylglycerol, and high HDL-cholesterol in serum. The DR, DR-F, and F groups had decreased myocardial lipoperoxide and lipid hydroperoxide. The DR-F and F treatments increased superoxide dismutase and glutatione peroxidase (GSH-Px). The DR treatment increased GSH-Px and catalase activities. Dietary fibre beneficial effects were related to metabolic alterations. The F and DR-F groups showed high cardiac glycogen and low lactate dehydrogenase/citrate synthase ratios, indicating diminished anaerobic and elevated aerobic myocardial metabolism in these animals. There was no synergistic effect between dietary restriction and dietary fibre addition, since no differences were observed in markers of oxidative stress in the F and DR-F groups. Dietary fibre supplementation, rather than energy intake and dietary restriction, appears to be the main process retarding oxidative stress in cardiac tissue.en
dc.description.affiliationPost Graduation Course Faculty of Medicine UNESP, Botucatu, São Paulo
dc.description.affiliationDepartment of Clinical Cardiology Faculty of Medicine UNESP, Botucatu, São Paulo
dc.description.affiliationDepartment of Statistics Institute of Biological Sciences UNESP, Botucatu, São Paulo
dc.description.affiliationDepartment of Morphology Institute of Biological Sciences UNESP, Botucatu, São Paulo
dc.description.affiliationDept. of Chemistry and Biochemistry Institute of Biological Sciences University Estadual Paulista, 18618-000 Botucatu, São Paulo
dc.description.affiliationUnespPost Graduation Course Faculty of Medicine UNESP, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Clinical Cardiology Faculty of Medicine UNESP, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Statistics Institute of Biological Sciences UNESP, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Morphology Institute of Biological Sciences UNESP, Botucatu, São Paulo
dc.format.extent1042-1048
dc.identifierhttp://dx.doi.org/10.1139/y03-097
dc.identifier.citationCanadian Journal of Physiology and Pharmacology, v. 81, n. 11, p. 1042-1048, 2003.
dc.identifier.doi10.1139/y03-097
dc.identifier.issn0008-4212
dc.identifier.scopus2-s2.0-0346729709
dc.identifier.urihttp://hdl.handle.net/11449/67459
dc.identifier.wosWOS:000186896100006
dc.language.isoeng
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.relation.ispartofjcr2.210
dc.relation.ispartofsjr0,724
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCardiac tissue
dc.subjectDietary fibre
dc.subjectDietary restriction
dc.subjectOxidative stress
dc.subjectbiological marker
dc.subjectcatalase
dc.subjectcholesterol
dc.subjectcitrate synthase
dc.subjectglutathione peroxidase
dc.subjectglycogen
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlactate dehydrogenase
dc.subjectlipid hydroperoxide
dc.subjectlipid peroxide
dc.subjectlow density lipoprotein cholesterol
dc.subjectsuperoxide dismutase
dc.subjecttriacylglycerol
dc.subjectaerobic metabolism
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectcholesterol blood level
dc.subjectcontrolled study
dc.subjectdiet restriction
dc.subjectdiet supplementation
dc.subjectenzyme activity
dc.subjectheart
dc.subjectheart disease
dc.subjectheart muscle metabolism
dc.subjectmale
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectrat
dc.subjecttriacylglycerol blood level
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCaloric Restriction
dc.subjectDietary Fiber
dc.subjectMale
dc.subjectMyocardium
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectRats, Wistar
dc.titleDietary restriction and fibre supplementation: Oxidative stress and metabolic shifting for cardiac healthen
dc.typeArtigo
dcterms.licensehttp://www.nrcresearchpress.com/page/authors/information/rights
unesp.author.lattes9418970103564137[2]
unesp.author.lattes8727897080522289[3]
unesp.author.orcid0000-0001-8741-1336[6]
unesp.author.orcid0000-0002-7719-9682[3]
unesp.author.orcid0000-0002-6122-0379[7]
unesp.author.orcid0000-0002-4402-6523[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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