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Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring

dc.contributor.authorNascimento, Amanda F.
dc.contributor.authorAlves, Glaucie Jussilane
dc.contributor.authorMassoco, Cristina O.
dc.contributor.authorTeodorov, Elizabeth
dc.contributor.authorFelicio, Luciano F.
dc.contributor.authorBernardi, Maria Martha [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2018-11-26T15:27:34Z
dc.date.available2018-11-26T15:27:34Z
dc.date.issued2015-01-01
dc.description.abstractObjective: The present study analyzed the effects of lipopolysaccharide (LPS) on maternal behavior during lactation and possible correlations with changes in emotional and immune responses in offspring. Methods: Lactating rats received 100 mu g/kg LPS, and the control group received saline solution on lactation day (LD) 3. Maternal general activity and maternal behavior were observed on LD5 (i.e. the day that the peak of fever occurred). In male pups, hematological parameters and ultrasonic vocalizations (USVs) were assessed on LD5. At weaning, an additional dose of LPS (50 mu g/kg, i.p.) was administered in male pups, and open-field behavior, oxidative burst and phagocytosis were evaluated. Results: A reduction in the time in which dams retrieved the pups was observed, whereas no effects on maternal aggressive behavior were found. On LD5, a reduction of the frequency of USVs was observed in pups, but no signs of inflammation were found. At weaning, an increase in immune system activity was observed, but no differences in open-field behavior were found. Conclusion: These results indicate that inflammation in lactating mothers disrupted mother/pup interactions and may have produced short- and long-term effects on pup behavior as well as biological pathways that modulate inflammatory responses to bacterial endotoxin challenge in pups. (C) 2014 S. Karger AG, Baselen
dc.description.affiliationUniv Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNIP, Grad Program Environm & Expt Pathol, Grad Program Dent, BR-04026002 Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ ABC, Math Comp & Cognit Ctr, Santo Andre, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNIP, Grad Program Environm & Expt Pathol, Grad Program Dent, BR-04026002 Sao Paulo, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/03912-0
dc.description.sponsorshipIdFAPESP: 2009/51886-3
dc.format.extent213-221
dc.identifierhttp://dx.doi.org/10.1159/000363350
dc.identifier.citationNeuroimmunomodulation. Basel: Karger, v. 22, n. 4, p. 213-221, 2015.
dc.identifier.doi10.1159/000363350
dc.identifier.fileWOS000353564000001.pdf
dc.identifier.issn1021-7401
dc.identifier.urihttp://hdl.handle.net/11449/158416
dc.identifier.wosWOS:000353564000001
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofNeuroimmunomodulation
dc.relation.ispartofsjr1,064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectLactation
dc.subjectMaternal care
dc.subjectUltrasonic vocalization
dc.subjectInflammation
dc.subjectImmune system
dc.titleLipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspringen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
dspace.entity.typePublication
unesp.author.orcid0000-0003-3945-9962[2]
unesp.author.orcid0000-0002-6860-9416[6]

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