Metronidazole-loaded polyethyleneimine and chitosan-based liquid crystalline system for treatment of staphylococcal skin infections

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dc.contributor.authorVictorelli, Francesca Damiani [UNESP]
dc.contributor.authorCalixto, Giovana Maria Fioramonti [UNESP]
dc.contributor.authorDos Santos Ramos, Matheus Aparecido [UNESP]
dc.contributor.authorBauab, Taís Maria [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:36:03Z
dc.date.available2018-12-11T17:36:03Z
dc.date.issued2018-01-01
dc.description.abstractStaphylococcus aureus is a common gram-positive bacterium of the human skin microbiota. It is also a dangerous pathogen that can cause serious and even lethal skin infections. The topical administration of metronidazole via nanotechnology-based drug delivery systems, such as liquid crystalline systems, can modulate both the drug permeation and activity, decreasing its side effects and increasing the drug potent activity against the gram-positive bacteria. This study aimed at: (1) structurally developing and characterizing a liquid crystalline systems composed of chitosan and polyethyleneimine dispersion as the aqueous phase, oleic acid as the oily phase, and ethoxylated and propoxylated cetyl alcohol as the surfactant (FPC) for metronidazole incorporation (0.5% w/w); (2) evaluating the in vitro release and skin permeation and retention properties of the metronidazole-loaded liquid crystalline systems (FPC-M); (3) investigating the in vitro antibacterial activity of FPC-M against Staphylococcus aureus. Polarised light microscopy indicated that both FPC and FPC-M are hexagonal systems. Rheological, texture, and bioadhesion assays showed that both are elastic and bioadhesive systems. According to the results of the in vitro release, permeation, and retention assays, FPC can modulate metronidazole release and allow metronidazole to stay for a longer time on the skin. The determination of FPC-M activity against Staphylococcus aureus showed that it could target the bacterial cell. In conclusion, the liquid crystalline systems developed in this study can improve the clinical performance of metronidazole in the treatment of staphylococcal skin infections.en
dc.description.affiliationSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: #2013/01565-1
dc.description.sponsorshipIdFAPESP: #2014/50928-2
dc.description.sponsorshipIdFAPESP: #2017/10016-2
dc.format.extent227-237
dc.identifierhttp://dx.doi.org/10.1166/jbn.2018.2484
dc.identifier.citationJournal of Biomedical Nanotechnology, v. 14, n. 1, p. 227-237, 2018.
dc.identifier.doi10.1166/jbn.2018.2484
dc.identifier.issn1550-7041
dc.identifier.issn1550-7033
dc.identifier.scopus2-s2.0-85042586099
dc.identifier.urihttp://hdl.handle.net/11449/179617
dc.language.isoeng
dc.relation.ispartofJournal of Biomedical Nanotechnology
dc.relation.ispartofsjr0,828
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectDrug Delivery System
dc.subjectLiquid Crystalline System
dc.subjectMetronidazole
dc.subjectNanotechnology
dc.subjectSkin Administration
dc.subjectStaphylococcal Skin Infections
dc.titleMetronidazole-loaded polyethyleneimine and chitosan-based liquid crystalline system for treatment of staphylococcal skin infectionsen
dc.typeArtigo
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas