Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer

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Kuasne, Hellen
Rodrigues, Iara Sant'Ana
Fuganti, Paulo Emilio
Losi-Guembarovski, Roberta
Ito, Kazuhiro
Kishima, Marina O.
de Freitas Rodrigues, Marco Aurelio
Rogatto, Silvia Regina [UNESP]
dos Santos, Rodrigo Mattos [UNESP]
de Syllos Colus, Ilce Mara

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Taylor & Francis Inc


The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06-2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21-2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.



AR gene, Gleason score, Histopathological parameters, Polymorphisms, Prostate Cancer, PSA gene

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Cancer Investigation. Philadelphia: Taylor & Francis Inc, v. 28, n. 9, p. 917-924, 2010.