SYNTHESIS; CHARACTERIZATION AND CYTOTOXIC ACTIVITY EVALUATION OF CYCLOPALLADATED COMPOUNDS CONTAINING ORTHOMETALLATED BENZALDEHYDEOXIME AND ETHYLENETHIOUREA AS LIGANDS

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Data

2018-12-01

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Coorientador

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Editor

Soc Brasileira Quimica

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Artigo

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Acesso abertoAcesso Aberto

Resumo

The halide bridge cleavage reaction of the [Pd(C-2,N-bzox)(mu-Cl)](2). compound (bzox = benzaldehydeoxime) with ethylenethiourea (L) in the 1:2 molar ratio at room temperature yielded the cyclopalladated compound [Pd(C-2,N-bzox)(Cl)(L)] (1) whose replacement of the halide group by the addition of suitable salts afforded compounds of general formulae [Pd((C-2,N-bzox)(X)(L)] = {X = Br- (2), I-(3)}. All compounds were characterized by melting point, elemental analyses, infrared and H-1- and C-13{H-1}-NMR spectroscopies revealing the complexes formation with the oxime coordinated to Pd(II) as C,N-chelating and the ethylenethiourea as a monodentate ligand via the sulfur atom. Hie cytotoxicity of cyclopalladated compounds has been evaluated in vitro against murine mammary tumor cell (LM3) showing cytotoxic activity similar to cisplatin.

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Português

Como citar

Quimica Nova. Sao Paulo: Soc Brasileira Quimica, v. 41, n. 10, p. 1150-1155, 2018.

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