Oral-Facial-Digital Syndrome Type 1: Oral Features in 12 Patients Submitted to Clinical and Radiographic Examination

Nenhuma Miniatura disponível




Tagliani, Marcela Martini [UNESP]
Gomide, Marcia Ribeiro
Carvalho Carrara, Cleide Felicia

Título da Revista

ISSN da Revista

Título de Volume


Alliance Communications Group Division Allen Press


Objective: To evaluate the oral features in individuals with oral-facial-digital syndrome type 1 (OFD 1), previously diagnosed by the Genetic Sector of the Hospital of Rehabilitation of Craniofacial Anomalies of the University of São Paulo (HRAC-USP).Design: Twelve patients with OFD 1 were examined clinically and radiographically; their medical files were also evaluated.Results: Associated oral malformations were observed in all patients (100%). The most frequent findings were tongue hamartomas, multiple buccal frena, asymmetric lips, asymmetric tongue, and bilateral maxillary gingival swelling. Interestingly, atrophy of the maxillary midline frenum was also observed in all the individuals examined.Conclusions: Several extra and intraoral alterations were observed in patients with OFD 1. The authors suggest the inclusion of atrophy of the maxillary midline frenum as a commonly found characteristic of OFD 1.



cleft lip and/or palate, craniofacial malformations, orofaciodigital syndrome

Como citar

Cleft Palate-craniofacial Journal. Lawrence: Alliance Communications Group Division Allen Press, v. 47, n. 2, p. 162-166, 2010.