CRF1 and CRF2 receptors in the bed nucleus of stria terminalis differently modulate the baroreflex function in unanesthetized rats

Página do item simplificado
dc.contributor.authorOliveira, Leandro A. [UNESP]
dc.contributor.authorAlmeida, Jeferson [UNESP]
dc.contributor.authorGomes-de-Souza, Lucas [UNESP]
dc.contributor.authorBenini, Ricardo [UNESP]
dc.contributor.authorCrestani, Carlos C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:13:06Z
dc.date.available2018-12-11T17:13:06Z
dc.date.issued2017-07-01
dc.description.abstractThe baroreflex is an important blood pressure regulating mechanism. The bed nucleus of stria terminalis (BNST) modulates the baroreflex function. However, the local BNST neurochemical mechanisms involved in control of baroreflex responses are not completely understood. Therefore, in this study, we investigated the involvement of corticotropin-releasing factor (CRF) receptors within the BNST in baroreflex control of heart rate in unanesthetized rats. For this, we evaluated effects of bilateral microinjection into the BNST of either the selective CRF1 receptor antagonist CP376395 (5 nmol/100 nL) or the selective CRF2 receptor antagonist antisauvagine-30 (5 nmol/100 nL) in bradycardiac response evoked by blood pressure increases caused by intravenous infusion of phenylephrine as well as tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside. Bilateral microinjection of CP376395 into the BNST decreased the baroreflex bradycardiac response without affecting the reflex tachycardia. Conversely, BNST treatment with antisauvagine-30 decreased heart rate response during blood pressure drop without affecting the reflex bradycardia. Overall, these findings provide evidence of an involvement of CRF neurotransmission within the BNST in baroreflex activity. Nevertheless, data indicate that local CRF1 and CRF2 receptors differently modulate the baroreflex control of heart rate.en
dc.description.affiliationLaboratory of Pharmacology Department of Natural Active Principles and Toxicology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário)
dc.description.affiliationJoint UFSCar-UNESP Graduate Program in Physiological Sciences PIPGCF
dc.description.affiliationUnespLaboratory of Pharmacology Department of Natural Active Principles and Toxicology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário)
dc.description.affiliationUnespJoint UFSCar-UNESP Graduate Program in Physiological Sciences PIPGCF
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2012/14376-0
dc.description.sponsorshipIdFAPESP: 2015/05922-9
dc.description.sponsorshipIdCNPq: 305583/2015-8
dc.description.sponsorshipIdCNPq: 456405/2014-3
dc.format.extent1805-1812
dc.identifierhttp://dx.doi.org/10.1111/ejn.13622
dc.identifier.citationEuropean Journal of Neuroscience, v. 46, n. 2, p. 1805-1812, 2017.
dc.identifier.doi10.1111/ejn.13622
dc.identifier.issn1460-9568
dc.identifier.issn0953-816X
dc.identifier.scopus2-s2.0-85021776933
dc.identifier.urihttp://hdl.handle.net/11449/174840
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Neuroscience
dc.relation.ispartofsjr1,757
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectbed nucleus of stria terminalis
dc.subjectcardiovascular system
dc.subjectcorticotropin-releasing factor
dc.subjecturocortin
dc.titleCRF1 and CRF2 receptors in the bed nucleus of stria terminalis differently modulate the baroreflex function in unanesthetized ratsen
dc.typeArtigo
unesp.author.lattes1117432571971568[5]
unesp.author.orcid0000-0002-1942-858X[5]

Arquivos

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR