Evaluation of photodynamic therapy on nanoparticles and films loaded-nanoparticles based on chitosan/alginate for curcumin delivery in oral biofilms

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dc.contributor.authorSilvestre, Amanda Letícia Polli [UNESP]
dc.contributor.authordos Santos, Aline Martins [UNESP]
dc.contributor.authorde Oliveira, Analú Barros [UNESP]
dc.contributor.authorFerrisse, Túlio Morandin [UNESP]
dc.contributor.authorBrighenti, Fernanda Lourenção [UNESP]
dc.contributor.authorMeneguin, Andréia Bagliotti [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T16:11:29Z
dc.date.available2023-07-29T16:11:29Z
dc.date.issued2023-06-15
dc.description.abstractNanoparticles and nanoparticle-loaded films based on chitosan/sodium alginate with curcumin (CUR) are promising strategies to improve the efficacy of antimicrobial photodynamic therapy (aPDT) for the treatment of oral biofilms. This work aimed to develop and evaluate the nanoparticles based on chitosan and sodium alginate encapsulated with CUR dispersed in polymeric films associated with aPDT in oral biofilms. The NPs were obtained by polyelectrolytic complexation, and the films were prepared by solvent evaporation. The photodynamic effect was evaluated by counting Colony Forming Units (CFU/mL). Both systems showed adequate characterization parameters for CUR release. Nanoparticles controlled the release of CUR for a longer period than the nanoparticle-loaded films in simulated saliva media. Control and CUR-loaded nanoparticles showed a significant reduction of 3 log10 CFU/mL against S. mutans biofilms, compared to treatment without light. However, biofilms of S. mutans showed no photoinactivation effect using films loaded with nanoparticles even in the presence of light. These results demonstrate the potential of chitosan/sodium alginate nanoparticles associated with aPDT as carriers for the oral delivery of CUR, offering new possibilities to improve the treatment of dental caries and infections. This work will contribute to advances in the search for innovative delivery systems in dentistry.en
dc.description.affiliationUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Pharmaceutics, SP
dc.description.affiliationUNESP São Paulo State University School of Dentistry Department of Restorative Dentistry, SP
dc.description.affiliationUNESP São Paulo State University School of Dentistry Department of Dental Materials and Prosthodontics, SP
dc.description.affiliationUnespUNESP São Paulo State University School of Pharmaceutical Sciences Department of Drugs and Pharmaceutics, SP
dc.description.affiliationUnespUNESP São Paulo State University School of Dentistry Department of Restorative Dentistry, SP
dc.description.affiliationUnespUNESP São Paulo State University School of Dentistry Department of Dental Materials and Prosthodontics, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2018/23096-7
dc.description.sponsorshipIdFAPESP: 2020/07110-0
dc.description.sponsorshipIdFAPESP: 2021/01191-0
dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2023.124489
dc.identifier.citationInternational Journal of Biological Macromolecules, v. 240.
dc.identifier.doi10.1016/j.ijbiomac.2023.124489
dc.identifier.issn1879-0003
dc.identifier.issn0141-8130
dc.identifier.scopus2-s2.0-85152924873
dc.identifier.urihttp://hdl.handle.net/11449/249872
dc.language.isoeng
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.sourceScopus
dc.subjectAntimicrobial photodynamic therapy
dc.subjectBuccal films
dc.subjectChitosan
dc.subjectCurcumin
dc.subjectPolymeric nanoparticles
dc.subjectSodium alginate
dc.titleEvaluation of photodynamic therapy on nanoparticles and films loaded-nanoparticles based on chitosan/alginate for curcumin delivery in oral biofilmsen
dc.typeArtigo
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas